Tag: Parkinson’s disease

Weekly Neuroscience Update

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Salk scientist finds similar rule governing traffic flow in engineered and biological systems.

An algorithm used for the internet may help researchers learn about the human brain, researchers report.

A new blood test may be as accurate as a test requiring a painful spinal tap for differentiating Parkinson’s disease from similar disorders, according to a study published in Neurology, the medical journal of the American Academy of Neurology.

Researchers report neurons move the site of microRNA maturation away from the cytoplasm out to the dendrites.

Emotions are not innately programmed into our brains, but, in fact, are cognitive states resulting from the gathering of information, researchers conclude in the latest issue of the journal Proceedings of the National Academy of Sciences.

A new study reveals some brain systems in a dish, dubbed circuitoids, exhibit coordinated and spontaneous rhythmic activity that can drive repetitive movements.

By using magnetic resonance imaging (MRI) to study the brains of infants who have older siblings with autism, scientists were able to correctly identify 80 percent of the babies who would be subsequently diagnosed with autism at 2 years of age.

An international research team has found that when the brain “reads” or decodes a sentence in English or Portuguese, its neural activation patterns are the same.

New findings suggest that language-specialised brain areas work in constant interaction with other areas known to support other cognitive processes, such as perception and action.

Scientists have identified two distinct mechanisms in the brain that control the balance between accuracy and speed when making decisions.

When it comes to perceiving music, the human brain is much more tuned in to certain types of rhythms than others, according to a new study.

The effects a concussion has on driving a vehicle may continue to linger even after the symptoms disappear, according to University of Georgia researchers.

Scientists say neurodegenerative diseases like Alzheimer’s and Parkinson’s may be linked to defective brain cells disposing toxic proteins that make neighbouring cells sick.

New research from Lund University in Sweden has shown that intestinal bacteria can accelerate the development of Alzheimer’s disease.

New research uncovers the brain circuit involved in processing fear, which could eventually lead to new treatment options for people with mental health disorders.

Finally this week, infants as young as 20 months of age expect adults to display surprise when discovering a false belief, according to a new study.

 

Weekly Neuroscience Update

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Our brain’s changing structure, not simply getting older and wiser, most affects our attitudes to risk, according to new research.

A new study from Center for Music in the Brain (MIB) Aarhus University/The Royal Academy of Music, Denmark, published in Scientific Reports, shows that participants receiving oxytocin – a hormone known to promote social bonding – are more synchronized when finger-tapping together, than participants receiving placebo. This effect was observed when pairs of participants, placed in separate rooms tapped together in a leader/follower relationship.

Researchers have identified a population of neurons that appear to be responsible for muscle paralysis during REM sleep.

A team of scientists has mapped out how our brains process visuals we don’t even know we’ve seen, indicating that the neuronal encoding and maintenance of subliminal images is more substantial than previously thought.

Mutations of the GBA gene, a known risk factor for Parkinson’s disease, appear to also influence the development of cognitive decline, a new study reports.

Women and men look at faces and absorb visual information in different ways, which suggests there is a gender difference in understanding visual cues, according to a team of scientists.

A new neuroimaging study finds iron is distributed in an unusual way in the brains of people with Parkinson’s disease.

Scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgements and memory recall.

A new study reveals sleep could be used as an early prevention strategy against PTSD.

Finally this week, researchers discover metaphors that involve body parts such as arms or legs, such as ‘twist my arm, engage a brain region responsible for the visual perception of those parts.

 

 

 

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Regions with significant phoneme classification at the NoNoise condition for each group. NeuroscienceNews.com image is credited to the researchers/Nature Communications.

Researchers have pinpointed the specific part of the brain that older adults rely on to differentiate speech sounds in background noise, which could revolutionise the treatment of hearing loss.

New research has identified how cells protect themselves against ‘protein clumps’ known to be the cause of neurodegenerative diseases including Alzheimer’s, Parkinson’s and Huntington’s disease.

Transcranial alternating current stimulation may help to improve memory when targeted to a specific kind of brain activity achieved during sleep.

Researchers in the US and Australia have made a breakthrough discovery in the international quest to discover a new and potentially effective vaccine targeting the pathological proteins associated with Alzheimer’s disease.

A new study identifies different brain regions that become active when a strategy of categorisation is applied.

Researchers have developed a new machine learning system that analyses the entire human genome to predict which genes may cause autism spectrum disorder, raising the number of genes that could be linked to the disorder from 65 to 2,500.

Results from a study published in the online publication Nature Genetics finds 15 genomic regions that are significantly associated with a diagnosis of depression.

According to researchers, age related changes in the organization of neural networks when performing short term memory tasks may help to compensate for other aspects of brain aging.

Researchers report smoking related deficits in dopamine return to normal three months after quitting.

Genetic changes associated with Parkinson’s disease have been found in liver, fat, immune and developmental cells, a new study reports.

Brain imaging, twin studies and transcriptome data reveal genetic relationships between lobes.

Finally this week, a new study suggests regular physical activity may lead to greater hippocampal volume and could stave off dementia, especially in older people.

 

 

 

 

 

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Sleep disturbances and long sleep duration are both associated with an increased risk for inflammation, a new study reports.

Abnormalities in brain regions involved in forming insight may help explain why some people with anorexia nervosa have trouble recognising their dangerous, dysfunctional eating habits.

A new study identifies different brain regions that become active when a strategy of categorisation is applied.

Researchers have identified – and shown that it may be possible to control – the mechanism that leads to the rapid build-up of the disease-causing ‘plaques’ that are characteristic of Alzheimer’s disease.

Using data from the largest ever genetic study of schizophrenia, researchers have shed light on the role of the immune system.

Using data from the Human Connectome Project, researchers have created a multimodal map of the human cortex that combines data from cortical architecture, function, connectivity, and topography. The map, detailed today (July 20) in Nature, identifies 180 brain areas, 97 of which are new to neuroscience.

A new study reports on how sensory neurons work together to transmit itch signals from the skin, via the spinal cord and to the brain.

A combination of transcranial magnetic stimulation and peripheral nerve stimulation may help in the rehabilitation of people with spinal cord injury, according to a new patient study conducted at the BioMag laboratory at the Helsinki University Hospital.

Researchers have discovered an interaction in neurons that contributes to Parkinson’s disease.

In a new study published in JAMA Neurology, researchers find stronger reason to be concerned about the long term effects of head injuries, particularly when it comes to Parkinson’s disease, which recently contributed to the death of Muhammad Ali.

Finally this week, researchers have identified how different parts of the brain interact with each other at different times in order to discover how intellect works.

 

 

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Cheese contains a chemical found in addictive drugs, scientists have found.

Chronic marijuana use disrupts the brain’s natural reward processes, according to researchers at the Center for BrainHealth at The University of Texas at Dallas.

Understanding the relation of dopamine to network activity could improve schizophrenia treatment.

Using MRI brain scans, researchers have determined there is an association between the extent of disruption to the blood-brain barrier and the severity of bleeding following a stroke.

Researchers have proposed a computational model that could help explain multisensory integration in humans.

Scientists have developed a blood test that could identify which people with depression will respond to treatment so that patients can avoid spending months taking antidepressants that do not help them.

Researchers have discovered a unique pattern of scarring in the brains of those who were exposed to blast brain injuries that differs from those exposed to other types of head injury.

Intensive physical exercise four hours after learning is the key to remembering information learnt, say Dutch researchers.

Scientists have discovered a new cause of Parkinson’s disease – mutations in a gene called TMEM230. This appears to be only the third gene definitively linked to confirmed cases of Parkinson’s disease.

Finally this week, a protein called Scribble appears to orchestrate the intracellular signaling process for forgetting, a new study reports.

 

Was dopamine the secret to Muhammad Ali’s greatness?

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Ali

I was saddened this week to read of the death of Muhammad Ali. The 74 year old whose outrageous talent in the ring was matched by his political significance and cultural impact, struggled with Parkinson’s disease which began during his boxing career in the late 1970’s. He was hospitalised several times in recent years and died of respiratory problems related to his disease. I have spent over 30 years investigating the effects of Parkinson’s disease on the brain and I am happy to report that during this period I have seen great strides in our understanding and treatment of this illness.

What is Parkinson’s disease?

Over 4 million people worldwide suffer from Parkinson’s disease; a so-called hypokinetic disorder (Greek; hypo = lack of; kinetic = movement). It is a progressive disease – the symptoms start out small and get progressively worse but it is rarely fatal. With Parkinson’s disease one minute you are working away in the garden and the next you are literally stuck to the spot – totally unable to move. In these situations daily life can become a challenge that can be difficult to endure.

Causes of Parkinson’s disease

Parkinson’s disease can be genetic but it can also be triggered by what happens to you as you live your life such as prolonged exposure to chemicals like insecticides, weed killers and some drugs. Significantly in the case of Muhammad Ali, the disease can also be triggered by brain injury. However in most cases Parkinson’s disease arises ‘out of the blue’ as the so-called idiopathic Parkinson’s disease.

The core defect

The ‘core defect’ in Parkinson’s disease is a loss of a chemical in the brain called dopamine. Dopamine acts like hydraulic oil which lubricates those nerve circuits in the brain that are involved in executing a movement. In Parkinson’s disease the supply of dopamine dries-up and, like a car out of oil the engine seizes-up and movement grinds to a halt.

The Muhammad Ali we all remember was dopamine in action

We need dopamine to survive. Dopamine allows us to talk, socialise, be brave, improvise and take risks. When dopamine flows we don’t see things as being limited by circumstance. We have boundless energy and literally anything is possible! One only needed to watch Muhammad Ali’s awesome talent at the height of his career to see dopamine in action as his brain effortlessly converted his thoughts into the mesmerising performances inside and outside the ring that made him so loved by a generation. Ali’s ability to ‘float like a butterfly, sting like a bee’ was all down to the dopamine in his brain.

Superman

As a child in the 1960s I thought this 6’ 3’’ giant was the closest thing to Superman. Later I watched him take on the establishment over the political and cultural discrimination against his African American heritage knowing full-well that they were going to make him pay for it. It was then that I realised that Muhammad Ali was not just a gifted athlete but also a courageous human being – that he was in fact, a real, live Superman. Again, Ali’s deeply-held convictions and his bravery in standing by them was another expression of the dopamine in his brain.

Was boxing to blame?

Since Muhammad Ali’s death some media have reported that it is a pity that his illness had to overshadow what he achieved during his amazing life. Without dopamine Ali must have felt trapped and disconnected at times. While neurologists cannot definitively say whether Ali’s symptoms were a result of his boxing career, what is known for certain is that head trauma increases the risk of getting Parkinson’s disease.

Boxing and brain injury – a potentially lethal mix

Probably the most important lesson to be taken from Ali’s illness is that we need to open up a debate on how we as a society deal with traumatic brain injury and its causes. Even a minor concussion is dangerous because repeat concussions have cumulative effects on the brain, resulting in brain swelling, permanent brain injury, and long-term disability including Parkinson’s disease, personality change, epilepsy or even death.

By its very nature, a concussion is unexpected, so it is difficult to prevent. Here are three common-sense precautions you can take to lessen the possibility of traumatic brain injury.

1. Wear protective head gear. Participation in high-contact, high-risk sports such as all types of boxing, football, hurling and hockey can increase the likelihood of a concussion. Skateboarding, snowboarding, horseback riding, cycling and roller-blading are also a threat to your brain health. Wearing headgear, padding, and mouth and eye guards can help safeguard against traumatic head injuries. Wearing a bike helmet can lower the risk of traumatic head injury by 85%. Ensure that the equipment is properly fitted, well maintained, and worn consistently.

2. Drive smart. Always wear a seatbelt even as a passenger in a back seat, obey posted speed limits, and don’t use drugs or alcohol when driving, because they can impair reaction time.

3. Don’t fight. Concussions are often sustained during a punch-up, and more males than females report traumatic head injuries.

Funding for research into illness of mind and brain

We also need to highlight the realisation that a deeper understanding of the brain IS the difference between a good and a bad quality of life for the sufferers of brain illnesses such as Parkinson’s disease.

I hope that Muhammad Ali’s loved ones will take hope from the on-going research into Parkinson’s disease by teams of dedicated scientists worldwide.

Click on this link to hear Professor Billy O’Connor talk about Parkinson’s disease on Mind Matters – a science program on Irish National radio (RTE).

You might also like to read:

Emotions are habits so pick a good one

World Mental Health Day

Why Parkinson’s Disease robbed Linda Ronstadt of her singing voice

 

 

Weekly Neuroscience Update

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Test subjects in an Ohio State University study were shown a series of photographs of different facial expressions. Researchers pinpointed an area of the brain that is specifically attuned to picking up key muscle movements (here, labeled AU for ‘action units’) that combine to express emotion. Credit: Ohio State University.

New machine learning algorithm can identify the facial expression a person is looking at based on neural activity.

After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair.

A new study reports hungry fish sense objects differently and take more risks when hunting than well fed fish.

In a study exploring the relationship between memory for specific past experiences and recovery from strong negative emotions, research psychologists report that episodic memory may be more important in helping midlife and older adults recover from a negative event than it is for younger adults.

New research reports one brain hemisphere remains more awake than the other when sleeping somewhere new. 

Long before Alzheimer’s disease can be diagnosed clinically, increasing difficulties building cognitive maps of new surroundings may herald the eventual clinical onset of the disorder, according to new research.

New research suggests actin filaments that control the shape of neuron cells may also be the key to the molecular machinery that forms and stores long-term memories.

Scientists have elucidated for the first time how a notoriously elusive serotonin receptor functions with atom-level detail. The receptor transmits electrical signals in neurons and is involved in various disorders, meaning that the discovery opens the way for new treatments.

Researchers have mapped out a circuit of neurons that is responsible for motor impairment–such as difficulty walking–in patients with Parkinson’s disease.

Brain waves that spread through the hippocampus are initiated by a method not seen before–a possible step toward understanding and treating epilepsy, according to researchers at Case Western Reserve University.

Researchers have conducted a study examining the effect ecstasy has on different parts of the brain.

Finally this week researchers have found that drawing pictures of information that needs to be remembered is a strong and reliable strategy to enhance memory.

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Dr. William Jagust explains how tau and beta amyloid, two proteins associated with Alzheimer’s disease, develop in the aging brain, which his research team has visualized using positron emission tomography, or PET, scans. Photo by Stephen McNally/University of California Berkeley

Researchers have visualized the development of Alzheimer’s disease in the brain in living people using positron emission tomography, or PET scans, which they say will aid with its diagnosis and treatment. 

Researchers have  also identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer’s disease, in a similar way to how statins are able to reduce the risk of developing heart disease.

A new study shows that a variety of physical activities from walking to gardening and dancing can improve brain volume and cut the risk of Alzheimer’s disease by 50%.

In another study jointly led by King’s College London and the University of Southampton has found a link between gum disease and greater rates of cognitive decline in people with early stages of Alzheimer’s Disease.

Women may have a better memory for words than men despite evidence of similar levels of shrinkage in areas of the brain that show the earliest signs of Alzheimer’s disease, according to a study published in Neurology.

Refugees face a substantially higher risk of psychotic disorders, including schizophrenia, compared to non-refugee migrants from the same regions of origin, finds a study published in The BMJ. 

Research on decision-making bias found that interactive training exercises using video games improved participants’ general decision-making abilities when used alongside other traditional training methods.

Reducing a person’s calorie intake can protect against the development of neurodegenerative diseases such as Parkinson’s Disease.  Meanwhile, researchers may be closer to unraveling the underlying causes of Parkinson’s disease, after identifying the point at which alpha-synuclein – a protein believed to play a key role in the condition – becomes toxic to the brain.

Scientists have developed a 3D micro-scaffold technology that promotes reprogramming of stem cells into neurons, and supports growth of neuronal connections capable of transmitting electrical signals.

Finally this week, researchers in Japan have found that repetitive movements in slow-learning stages can alter an area of the brain responsible for movement, and help individuals retain these motor skills.

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SNTF stained axons (brown) shortly after traumatic brain injury are pictured. The undulating course suggests damage to the internal skeleton, and the SNTF stain shows the high calcium concentration- activated enzymes that destroy the axon from the inside out. Credit: The laboratory of Douglas Smith, MD, Perelman School of Medicine, University of Pennsylvania.

SNTF stained axons (brown) shortly after traumatic brain injury are pictured. The undulating course suggests damage to the internal skeleton, and the SNTF stain shows the high calcium concentration- activated enzymes that destroy the axon from the inside out. Credit: The laboratory of Douglas Smith, MD, Perelman School of Medicine, University of Pennsylvania.

Physicians and others now recognize that seemingly mild, concussion-type head injuries lead to long-term cognitive impairments surprisingly often. A brain protein called SNTF, which rises in the blood after some concussions, signals the type of brain damage that is thought to be the source of these cognitive impairments, according to a new study.

About one third of people with depression have high levels of inflammation markers in their blood. New research indicates that persistent inflammation affects the brain in ways that are connected with stubborn symptoms of depression, such as anhedonia, the inability to experience pleasure.

Scientists have reported measurements of dopamine release with unprecedented temporal precision in the brains of people with Parkinson’s disease. The measurements, collected during brain surgery as the conscious patients played an investment game, demonstrate how rapid dopamine release encodes information crucial for human choice.

Scientists have uncovered a mechanism in the brain that could account for some of the neural degeneration and memory loss in people with Alzheimer’s disease.

Regardless of gender, young adults who have greater aerobic fitness also have greater volume of their entorhinal cortex, an area of the brain responsible for memory. Better aerobic fitness however does not appear to impact hippocampal volume, another area in the brain responsible for memory.

A new scientific model that incorporates the myriad drivers of depression could lead to more precise treatment for an illness that affects 350 million worldwide.

Finally this week, could staying physically active improve quality of life by delaying cognitive decline and prolonging an independent lifestyle? A new study has found that older adults who take more steps either by walking or jogging perform better on memory tasks than those who are more sedentary.

 

 

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Total correct score on the Eyes test for each individual is plotted as a dot, coloured according to group, to illustrate the distribution of performance by group. Mean score for each group is shown by a black dot, and the error bars indicate the 95% confidence interval of the mean score. Credit: Baron-Cohen et al./PLOS ONE.

Total correct score on the Eyes test for each individual is plotted as a dot, coloured according to group, to illustrate the distribution of performance by group. Mean score for each group is shown by a black dot, and the error bars indicate the 95% confidence interval of the mean score. Credit: Baron-Cohen et al./PLOS ONE.

New results published by researchers at the Autism Research Centre (ARC) show both men and women with autism show an extreme of the typical male pattern on the ‘Reading the Mind in the Eyes’ test.

Researchers at Mayo clinic completed analysis of a 4 year prospective study comparing detailed neurologic examination versus magnetic resonance imaging (MRI) of the brain to localize neurologic dysfunction. The findings, demonstrated MRI’s superior performance to the clinical exam.

Researchers at the University of Oslo have tested a new device for delivering hormone treatments for mental illness through the nose. This method was found to deliver medicine to the brain with few side effects.

Researchers have performed the first focused ultrasound treatments in the United States for dyskinesia associated with Parkinson’s disease.

A computer-based brain-training game could improve the daily lives of people with schizophrenia, say University of Cambridge researchers.

A gene linked in previous research, appears to predict more severe post-traumatic stress disorder (PTSD) symptoms as well as a thinner cortex in regions of the brain critical for regulating strong emotions and coping with stressful experiences. This study is believed to be the first to show that the spindle and kinetochore-associated complex subunit 2 (SKA2) gene may play a role in the development of PTSD.

Midday naps are associated with reduced blood pressure levels and prescription of fewer antihypertensive medications, according to new research.

A ‘gene signature’ that could be used to predict the onset of diseases, such as Alzheimer’s, years in advance has been developed in research published in the open access journal Genome Biology.