Mind-controlled artificial limb gives patients sense of touch again

Researchers at Case Western Reserve University used a flat interface nerve electrode (FINE) to demonstrate direct sensory feedback. By interfacing with residual nerves in the patient’s partial limb, some sense of touch by the fingers is restored. Other existing prosthetic limb control systems rely solely on visual feedback. Unlike visual feedback, direct sensory feedback allows patients to move a hand without keeping their eyes on it—enabling simple tasks, like rummaging through a bag for small items, not possible with today’s prosthetics.

This Case Western Reserve University video shows how direct sensory feedback makes some tasks easier. The FINE is one of many different types of nerve interfaces developed under the RE-NET program.

Full story at http://go.usa.gov/bbV4.

Why you shouldn’t cram your brain before an exam

Synapses

It’s well known that synapses in the brain, the connections between neurons and other cells that allow for the transmission of information, grow when they’re exposed to a stimulus. Now new research from the lab of Carnegie Mellon Associate Professor of Biological Sciences Alison L. Barth has shown that in the short term, synapses get even stronger than previously thought, but then quickly go through a transitional phase where they weaken.

“When you think of learning, you think that it’s cumulative. We thought that synapses started small and then got bigger and bigger. This isn’t the case,” said Barth. “Based on our data, it seems like synapses that have recently been strengthened are peculiarly vulnerable — more stimulation can actually wipe out the effects of learning.”

Psychologists know that for long-lasting memory, spaced training — like studying for your classes after very lecture, all semester long — is superior to cramming all night before the exam. This study shows why. Right after plasticity, synapses are almost fragile — more training during this labile phases is actually counterproductive.

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Weekly Neuroscience Update

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Scientists have shown that working as a piano tuner may lead to changes in the structure of the memory and navigation areas of the brain. The study, published in the Journal of Neuroscience, shows that these structural differences correlate with the number of years of experience a piano tuner has accumulated.

An unusual kind of circuit fine-tunes the brain’s control over movement and incoming sensory information, and without relying on conventional nerve pathways, according to a study published in the journal Neuron.

The reason we struggle to recall memories from our early childhood is down to high levels of neuron production during the first years of life, say Canadian researchers.

Researchers have identified mutations in several new genes that might be associated with the development of spontaneously occurring cases of the neurodegenerative disease known as amyotrophic lateral sclerosis, or ALS. Also known as Lou Gehrig’s disease, the progressive, fatal condition, in which the motor neurons that control movement and breathing gradually cease to function, has no cure.

The brains of people with depression show a reduced ability to adapt to their environment, a unique study shows.

Researchers at the Stanford University School of Medicine have found that a naturally occurring protein secreted only in discrete areas of the mammalian brain may act as a Valium-like brake on certain types of epileptic seizures.

photo credit: Chandra Marsono via photopin cc

Patient Plays Guitar During Brain Surgery To Treat Parkinson’s

Brad Carter Plays Guitar During Brain Surgery To Treat Parkinson’s

To mark Ronald Reagan UCLA Medical Center’s 500th deep brain stimulation operation last Thursday, surgeons performed the world’s first live-Vined brain surgery.

The operation, which lead neurologist Dr. Nader Pouratian described as “textbook” brain pacemaker implant surgery, was documented with Vine, a six-second video medium, and with Instagram photos on the hospital’s Twitter account in real time on patient Brad Carter, an actor diagnosed with the progressive neurological disorder essential tremor in 2006.

“Not everyone gets to experience a surgery, and more specifically an awake brain surgery,” Pouratian said in a phone interview with The Huffington Post. “I thought it was a great opportunity to share with the world.”

Deep brain stimulation is a therapy for people with Parkinson’s disease, that  involves inserting a pacemaker that emits electronic impulses to affected areas of the brain, lessening tremor symptoms. At UCLA, the patient is conscious during the surgery and is asked to perform tests so that doctors can ensure the pacemaker is properly placed.

Carter’s disease made his hands shake and his eyes twitch, affecting his ability to play the guitar. He had asked that he be allowed to strum his guitar during the operation to see if the pacemaker improved his playing ability.
Vine videos from the surgery show Carter’s guitar skills get stronger as physicians located the best place to leave the pacemaker.

Weekly Neuroscience Update

This image from the study shows changes in degree of connectivity in the feedback group. Increases are shown in red/yellow and decreases in blue/purple. Decreases in connectivity are seen in limbic areas, and increases are seen in prefrontal regions. (Credit: D Scheinost et al./Yale University)

People provided with a real-time readout of activity in specific regions of their brains can learn to control that activity and lessen their anxiety, say Yale researchers.

A new study provides neurobiological evidence for dysfunction in the neural circuitry underlying emotion regulation in people with insomnia, which may have implications for the risk relationship between insomnia and depression.

Different brain areas are activated when we choose for ourselves to suppress an emotion, compared to situations where we are instructed to inhibit an emotion, according to a new study from the UCL Institute of Cognitive Neuroscience and Ghent University.

Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.

The epigenetic modifications, which alter the way genes function without changing the underlying DNA sequence, can apparently be detected in the blood of pregnant women during any trimester, potentially providing a simple way to foretell depression in the weeks after giving birth, and an opportunity to intervene before symptoms become debilitating.

A three-year multinational study has tracked and detailed the progression of Huntington’s disease (HD), predicting clinical decline in people carrying the HD gene more than 10 years before the expected onset of symptoms.

Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain.

Individuals who learn two languages at an early age seem to switch back and forth between separate “sound systems” for each language, according to new research conducted at the University of Arizona.

Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or under-react in response to stressful tasks, such as recalling a traumatic event or reacting to a photo of a threatening face. Now, researchers at NYU School of Medicine have explored for the first time what happens in the brains of combat veterans with PTSD in the absence of external triggers.

And finally this week…

Listening to new music is rewarding for the brain, a study suggests. Using MRI scans, a Canadian team of scientists found that areas in the reward centre of the brain became active when people heard a song for the first time. The more the listener enjoyed what they were hearing, the stronger the connections were in the region of the brain called the nucleus accumbens. The study is published in the journal Science

A Theory Of Mind

The mechanism people use to infer and reason about another person’s states of mind is called a ‘Theory of Mind’ . One of the most striking discoveries of recent human cognitive neuroscience is that there is a group of brain regions in human cortex that selectively and specifically underlie this mechanism.

In this Ted Talk, cognitive neuroscientist, Rebecca Saxe shares fascinating lab work that uncovers how the brain thinks about other peoples’ thoughts — and judges their actions.

Our lab studies these brain regions for Theory of Mind, as a case study in the deeper and broader question: how does the brain – an electrical and biological machine – construct abstract thoughts?

Weekly Neuroscience Update

Different brain areas are activated when we choose to suppress an emotion, compared to when we are instructed to inhibit an emotion, according to a new study.

Researchers say signs of psychopathy could be detected as early as childhood. The conclusion was drawn from a study where psychologists scanned the brains of children with conduct problems. When the children were shown images of someone in pain, regions of the brain associated with empathy remained inactive.

Using MRI, neuroscientists have found significant differences in brain anatomy when comparing men and women with dyslexia to their non-dyslexic control groups, suggesting that the disorder may have a different brain-based manifestation based on sex.

Research into the comparative size of the frontal lobes in humans and other species has determined that they are not – as previously thought – disproportionately enlarged relative to other areas of the brain, according to the most accurate and conclusive study of this area of the brain.  It concludes that the size of our frontal lobes cannot solely account for humans’ superior cognitive abilities.

When the brain’s primary “learning center” is damaged, complex new neural circuits arise to compensate for the lost function, say researchers who have pinpointed the regions of the brain involved in creating those alternate pathways — often far from the damaged site.

Your brain often works on autopilot when it comes to grammar. That theory has been around for years, but University of Oregon neuroscientists have captured elusive hard evidence that people indeed detect and process grammatical errors with no awareness of doing so.

Image Credit: © Tryfonov / Fotolia

Weekly Neuroscience Update

Getting a grip—literally— by clenching your right fist before remembering information and your left when you want to remember it can boost your recall, according to the latest study. This strange trick may work because clenching your hands activates the side of the brain that handles the function— in right-handed people, for instance, the left side of the brain is primarily responsible for encoding information and the right for recalling memory. (If you are left-handed, the opposite applies).

Mathematicians from Queen Mary, University of London will bring researchers one-step closer to understanding how the structure of the brain relates to its function in two recently published studies.

Greater adherence to a Mediterranean diet (MeD) is associated with a lower likelihood of incident cognitive impairment (ICI), especially among those without diabetes, according to a study published in the April 30 issue of Neurology.

The widespread belief that dopamine regulates pleasure could go down in history with the latest research results on the role of this neurotransmitter. Researchers have proved that it regulates motivation, causing individuals to initiate and persevere to obtain something either positive or negative.

Supposedly ‘primitive’ reflexes may involve more sophisticated brain function than previously thought, according to researchers at Imperial College London.

The production of a certain kind of brain cell that had been considered an impediment to healing may actually be needed to staunch bleeding and promote repair after a stroke or head trauma, researchers at Duke Medicine report.

For any addiction, external  cues and stress can trigger  cravings that are hard to resist, and the latest research points to an area of  the brain that might be responsible  for sabotaging recovery.