Weekly Neuroscience Update

April 10, 2016Leave a comment

alzheimers-synapse-loss

Researchers show how brain connections, or synapses, are lost early in Alzheimer’s disease and demonstrate that the process starts, and could potentially be halted, before telltale plaques accumulate in the brain.

Older adults who exercise regularly could buy an extra decade of good brain functioning, a new study suggests.

Researchers have identified an area of the brain that helps us to perceive boundaries.

Using a sophisticated MRI technique, researchers have found abnormalities in the brain’s white matter tracts in patients with insomnia. Results of the study were published online in the journal Radiology.

A pioneering new study has revealed how an individual’s movement can give a unique insight into their inherent personality traits.

The fluctuations of your heartbeat may affect your wisdom, according to new research.

Researchers have found that the emotional impact experienced by music listeners depends on the concert hall’s acoustics.

Lysergic acid diethylamide (LSD) use causes changes in the way that people think about time that may help develop drug therapies for people suffering from depression, according to a study published in the Journal of Psychopharmacology.

Repeated minor trauma to the head and other body parts can lead to early dementia, according to a new study.

The risk of schizophrenia in children associated with younger and older maternal age appears to be partly explained by the genetic association between schizophrenia and age at first birth, according to an article published online by JAMA Psychiatry.

A new imaging study shows that intense exercise boosts two critical neurotransmitters — glutamate and gamma-aminobutyric acid (GABA) — resulting in better mental fitness.

Religion and science activate different networks in the brain and each suppresses the other, new research finds.

Sensory neurons in human muscles provide important information used for the perception and control of movement. Learning to move in a novel context also relies on the brain’s independent control of these sensors, not just of muscles, according to a new study published in the journal Current Biology.

Finally this week, women with Alzheimer’s have poorer cognitive abilities than men at the same stage of the disease, according to a new paper published in World Journal of Psychiatry.

Weekly Neuroscience Update

February 5, 2016February 5, 2016Leave a comment

hypothalamus-genetics-obesity

Credit: BruceBlaus

Scientists have discovered a new genetic syndrome of obesity, over-eating, mental and behavioural problems in six families, from across the world. The study represents an important step in our understanding of how the hypothalamus and oxytocin control appetite and behaviour.

A new study published in Biological Psychiatry suggests that a brain reward centre, the striatum, may be directly affected by inflammation and that striatal change is related to the emergence of illness behaviors.

By studying stroke patients who have lost the ability to spell, researchers have pinpointed the parts of the brain that control how we write words.

A study has shown for the first time that the structure of the brain circuitry known as the corticolimbic system is more likely to be passed down from mothers to daughters than from mothers to sons or from fathers to children of either gender. The corticolimbic system governs emotional regulation and processing and plays a role in mood disorders, including depression.

New research proves that suffering repeated traumatic experiences throughout infancy and adolescence multiplies by 7 the risk of suffering psychosis during adulthood.

Researchers are using a mathematical tool to help determine which concussion patients will go on to suffer migraine headaches, according to a new study published online in the journal Radiology.

Some of the earliest nerve cells to develop in the womb shape brain circuits that process sights and sounds, but then give way to mature networks that convert this sensory information into thoughts. This is the finding of a study led by researchers at NYU Langone Medical Center and published in the February 3 edition of Neuron.

Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS.

New research indicates that the location of receptors that transmit pain signals IS important in how big or small a pain signal will be and how effectively drugs can block those signals.

A new way of using MRI scanners to look for evidence of multiple sclerosis in the brain has been successfully tested by researchers.

A team of European researchers has found evidence that suggests that human consciousness is a state where the neural network that makes up the brain operates at an optimal degree of connectedness. In their paper published in Journal of the Royal Society Interface, the team describes their study of the human brain using volunteers undergoing fMRI scans while succumbing to the effects of an anesthetic that caused them to lose consciousness, and what was revealed in reviewing the scan data.

Researchers have determined that testing a portion of a person’s submandibular gland may be a way to diagnose early Parkinson’s disease.

Finally this week, researchers of a new study published in the current issue of Biological Psychiatry report successful reduction of depressive symptoms in patients using a novel non-invasive method of vagus nerve stimulation, or VNS.

Inside the Mind of Alzheimer’s (Video)

January 19, 20161 Comment

Greg O’Brien is the author of On Pluto: Inside the Mind of Alzheimer’s. It is the first book written by an investigative reporter embedded inside the mind of Alzheimer’s chronicling the progression of his own disease. On Pluto has won several international book awards, and has been the subject of numerous television, radio, newspaper and magazine stories.

Weekly Neuroscience Update

January 17, 2016January 17, 2016Leave a comment

A new study presented in the journal Nature could change the view of the role of motor neurons. Motor neurons, which extend from the spinal cord to muscles and other organs, have always been considered passive recipients of signals from interneuronal circuits. Now, however, researchers from Sweden´s Karolinska Institutet have demonstrated a new, direct signalling pathway through which motor neurons influence the locomotor circuits that generate rhythmic movements.

Neuroimaging studies suggest that frontolimbic regions of the brain, structures that regulate emotions, play an important role in the biology of aggressive behaviour.

A team of researchers has discovered that differences in the types of memories we have influence the nature of our future encounters. Their findings show how distinct parts of the brain, underlying different kinds of memories, also influence our attention in new situations.

A gene involved in the regulation of emotions and behaviour could influence the long-term impact of violence experienced in childhood on antisocial behaviour.

Nerve cells have to react extremely quickly, but depending on the task they are supposed to perform they often need to work more slowly. Berlin scientists have now shown that a receptor in the synapse can adapt to follow both regimes. It’s another example of the amazing flexibility of the brain, manifested at the molecular level.

A new treatment aimed at clearing abnormal clumps of protein called tau tangles from the brain in Alzheimer’s disease is entering an early-stage clinical trial in the UK.

Scientists have identified a cerebral marker specific to autism that can be detected by MRI and is present as from the age of two years. The abnormality thus detected consists in a less deep fold in Broca’s area, a region of the brain specialized in language and communication, functions that are impaired in autistic patients. This discovery may assist in the earlier diagnosis and management of these patients.

A research initiative exploring the utility of genetic information in the clinical setting has published a study and identified six noteworthy genes that affect human sleep duration.

Individuals addicted to cocaine may have difficulty in controlling their addiction because of a previously-unknown ‘back door’ into the brain, circumventing their self-control, suggests a new study led by the University of Cambridge.

A simple, computer-training task can change the brain’s wiring to regulate emotional reactions, according to a recent study published in NeuroImage.

The workings of neural circuits associated with creativity are significantly altered when artists are actively attempting to express emotions, according to a new brain-scanning study of jazz pianists.

Finally this week, a new study has found that blocking a receptor in the brain responsible for regulating immune cells could protect against the memory and behaviour changes seen in the progression of Alzheimer’s disease.

Weekly Neuroscience Update

August 21, 2015Leave a comment

The link between vision problems and schizophrenia is well established, with as many as 62 percent of adult patients with schizophrenia experience visual distortions involving form, motion, or color. Image is for illustrative purposes only. Credit: University of Bristol.

New research has identified the mechanisms that trigger disruption in the brain’s communication channels linked to symptoms in psychiatric disorders including schizophrenia. The study, published in the Proceedings of National Academy of Sciences, could have important implications for treating symptoms of brain disorders.

Genetic analysis of human patients has shown that mutations in genes involved in synaptic communication can drive neuropsychiatric and neurological diseases such as autism spectrum disorder and Alzheimer’s disease.

Researchers have discovered a way to predict human emotions based on brain activity.

Working 55 hours or more per week is linked to a 33% greater risk of stroke compared with working a standard 35 to 40 hour week, according to the largest study in this field so far, published in The Lancet.

The permanence of memories has long thought to be mediated solely by the production of new proteins. However, new research has shown that the electrical activity of the brain may be a more primary factor in memory solidification.

The hippocampus in the brain’s temporal lobe is responsible for more than just long-term memory. Researchers have for the first time demonstrated that it is also involved in quick and successful conflict resolution

A brief period of postnatal visual deprivation, when early in life, drives a rewiring of the brain areas involved in visual processing, even if the visual restoration is completed well before the baby reaches one year of age, researchers revealed in Current Biology.

New research published in the British Journal of Psychiatry suggests that serious disorders of mood such as bipolar disorder may be the price that human beings have had to pay for more adaptive traits such as intelligence, creativity and verbal proficiency.

Finally this week, people with psychopathic characteristics are less likely to be affected by “contagious yawning” than those who are empathetic, according to a Baylor University psychology study.

Weekly Neuroscience Update

August 15, 2015Leave a comment

$math-model-memory$

Human memory is the result of different mental processes, such as learning, remembering and forgetting. However, these distinct processes cannot be observed directly. Researchers have now succeeded at describing them using computational models. The scientists were thus for the first time able to identify gene sets responsible for steering specific memory processes. Their results have been published in the current issue of the journal PNAS.

A new study has demonstrated how stress can influence regions of the brain involved with self-control.

A groundbreaking new study has found for the first time that emotions are not only the product of the processing of information by the brain, but that they also directly influence processes of learning and memory in the brain.

A new study suggests that your fat tissue can send mixed signals to your brain when stress strikes.

The brains of people with epilepsy appear to react to music differently from the brains of those who do not have the disorder, a finding that could lead to new therapies to prevent seizures, according to research presented at the American Psychological Association’s 123rd Annual Convention.

Researchers have discovered a way to predict human emotions based on brain activity.

Recent research published in the journal Microsystems & Nanoengineering could eventually change the way people living with prosthetics and spinal cord injury lead their lives.

A growing body of research suggests a link between kidney impairment and brain disorders.

A new study may have unlocked understanding of a mysterious part of the brain — with implications for neurodegenerative conditions such as Alzheimer’s. The results, published in Translational Vision Science & Technology (TVST), open up new areas of research in the pursuit of neuroprotective therapies.

Children who suffer an injury to the brain — even a minor one — are more likely to experience attention issues.

New research has identified a novel learning and memory brain network that processes incoming information based on whether it’s something we’ve experienced previously or is deemed to be altogether new and unknown, helping us recognize, for instance, whether the face before us is that of a familiar friend or a complete stranger.

Finally, this week, A new study sheds light on what motivates people to trust.

15 ways to stave off dementia

August 10, 2015August 10, 2015Leave a comment

Evidence suggests that if key risk factors for dementia – such as poor nutrition, lack of exercise and unhealthy lifestyles – were addressed, fewer people would have it. In today’s post I suggest fifteen ways you may be able to stave off dementia.

1 Wear a helmet
Head injury has been linked to early onset of Alzheimer’s later in life. Some boxers, as well as people who otherwise suffer a head injury, can have a higher risk of contracting Alzheimer’s disease, which constitutes about 70pc of dementia cases. It’s therefore wise to make a point of wearing a helmet if you play sports which can result in a head injury. For the same reason, it’s also a very good idea to always wear your seat-belt in the car.

2 Eat Fish
A diet rich in fish is a diet low in cholesterol. When the medical profession started to treat high cholesterol with cholesterol-lowering medication called statins, they discovered they could also delay the onset of dementia for about seven years. Statins may be helpful to people who show signs of early-onset dementia.

3 Use It or Lose It

Keep your brain active. It’s a case of use it or lose it. The more you challenge the brain, as you do in education, the fitter and healthier it becomes, which means it can withstand attack in older age from problems such as stress, depression or trauma. The more educated you are and the more effective you’ve been in using your brain during your life, the stronger its ability to resist attack. Interestingly, people who are by nature curious tend, on average, to develop Alzheimer’s much later in life than people who are not.

4 Eat less sugar

Scientists now believe there is an association between hypoglycaemia and dementia.Most people with type two diabetes develop the diabetes because they eat so much sugary food and take so little exercise that the body cannot handle the sugar. New research has shown that diabetes, and the rebound hypoglycaemia (low blood sugar) it causes, may exacerbate the risk of developing dementia and Alzheimer’s disease. The brain uses glucose (sugar) as a primary source of energy, and cognitive function becomes impaired when blood glucose drops to low levels. Basically, diabetes impairs the production and regulation of insulin which helps blood cells take up glucose. This means that for diabetics, getting a regular supply of glucose to the brain is more difficult. Scientists now believe that when the brain is starved of energy, neurological problems like dementia and Alzheimer’s are more likely to develop.

5 Lose weight

Scientists now believe there is a link between midlife obesity and a higher risk of developing dementia. Once the body is extremely overweight or obese, t he fat becomes metabolically or chemically unstable and can become inflamed. That inflammation may then spread around the body – including to the brain. Inflammation in the brain is believed to be linked to dementia.

6 Don’t smoke

Smoking obstructs the lungs, and can cause chronic obstructive pulmonary disease. This means the lungs are not able to get as much oxygen as they need and you end up damaging the lungs, and the lung tissue. Insufficient oxygen supplies to the brain lowers the brain’s energy levels, thereby impairing its ability to protect itself. Meanwhile, the nicotine damages blood vessels everywhere in the body, including in the brain. By damaging the blood vessels, nicotine can help cause high blood pressure and damage the nerves in the brain.

7 Treat your depression

It’s now believed that depression can be a factor in the onset of dementia. There is evidence now that depression may be a brain inflammation in the frontal part of the brain – while Alzheimer’s is an inflammation in the hippocampus. If you’re suffering from depression, get it treated, because inflammation weakens the ability of the brain to fight infection. Depression is also about withdrawal from society so being depressed means you’re less open to doing things and that means you aren’t challenging your brain.

8 Be physically active

If you’re physically inactive, you’re not introducing oxygen to the body – and the brain needs huge amounts of oxygen because it’s so active, even during the night. The brain can use more oxygen in some phases of sleep than when we’re awake during the day. Depriving the brain of oxygen prevents it from learning, i.e. making new connections and repairing itself – let alone getting on with the normal processes of growth and development.

9 Watch Your Blood Pressure

High blood pressure is a major cause of stroke, which deprives the brain of life-giving oxygen. You can end up with dementia through a series of mini-strokes. These can gradually lead to a change in the person’s character, which eventually, without appropriate treatment, may develop into full-blown dementia. So avoid a lifestyle which can contribute to high blood pressure – reduce your stress levels, make sure you get sufficient, good quality sleep and avoid drugs linked to high blood pressure such as nicotine.

10 Get that ingrown toenail treated!

Seriously – never allow an infection in the body to persist. If you do, it may spread and, over a series of decades, can result in an inflammation which spreads to the brain and may result in dementia. When we develop an infection, the body responds with a series of chemicals which are supposed to fight it. However, if the infection persists, and goes untreated, these ‘warrior’ chemicals can spread throughout the body. They can eventually become indiscriminate in what they fight, so instead of fighting infection, they start to fight the body including the brain.

11 Nutrition

Make sure your diet includes lots of vegetables, particularly green leafy ones, and fruit, herbs like rosemary and sage and plenty of fish oil. Vegetables and fruit are packed with health-giving antioxidants which stop inflammation. Antioxidants are like a fire-blanket on inflammation. Eat the rosemary and sage which are cognitively enhancing because they contain chemicals which replace the main neurotransmitter damaged in dementia – acetycholine – which is involved in high-level thought. Make sure your diet also includes good-quality fish oil – try having sardines on toast once a week, for example. Fish oil is used by the body to make the chemicals to fight inflammation. And drink coffee. People who drink it are less predisposed to Alzheimer’s. It’s a psychological stimulant and a cognitive-enhancing drug.

12 Watch TG4!

Brush up on your Irish – there’s evidence to show that having a second language can help protect you from the onset of dementia. It has been discovered that learning a second language exercises the brain so much that it strengthens it and makes it more resistant to fighting the injuries and infection which often result in dementia. A Swiss study carried out in the last few years has showed that bilingualism and multilingualism seems to offer protection again the onset of dementia.”

13 Buy a Smartphone and play video games

Get a smartphone because it’s good for your brain to work out how to use it properly, especially if you’re older. Play video games with your grandchildren – it will help to keep you mentally on your toes; while playing bridge either with your friends or online is a great way to wake up the brain. Bridge is a game of memory and strategy. It’s very challenging for the brain and is also a highly sociable activity.

14 Try some brain-teasers

Use your non-preferred hand once in a while for activities such as brushing your teeth or hair. This challenges your brain because you are carrying out an unfamiliar activity. Try wearing your wristwatch upside down – this also forces your brain to do some work. It requires the hippocampus (the area of the brain which is the most vulnerable to dementia) to do a mental rotation in order to work out the correct time from the dial. And try learning to juggle – this is a great exercise in hand-eye coordination because it involves both physical activity and mental concentration. Go buy three oranges now and get on with it. It’s part of a brain-building process which helps your brain fight the injury and infection that may lead to dementia.

15 Get creative! Doodle

Instead of just looking at art or just listening to music, make your own. Write songs, paint a picture, learn to play an instrument, sing or dance. First of all, it’s physically active, and secondly you’re thinking about what you are doing. Your brain is planning and working instead of simply receiving information. Make a point of regularly reading challenging material and do 30-minute word searches on Google, picking a word, for example ‘starling’, and finding out everything there is to know about these birds. It’s also good to doodle. Doodling is a healthy mental exercise because it is a creative act. It’s a sign that what you’re currently doing is not sufficiently challenging. Doodling is positive because it’s a creative and focused activity.

Adapted from The Irish Independent

Weekly Neuroscience Update

June 12, 2015June 12, 2015Leave a comment

This image shows an overview of the Rehabilitation Gaming System. Image credit: Rehabilitation Gaming System.

Using virtual reality to increase a patient’s confidence in using their paralyzed arm may be critical for recovery, according to research published in the open-access Journal of NeuroEngineering and Rehabilitation.

A pioneering study conducted by leading researchers at the University of Sheffield has revealed blood types play a role in the development of the nervous system and may cause a higher risk of developing cognitive decline. The findings seem to indicate that people who have an ‘O’ blood type are more protected against the diseases in which volumetric reduction is seen in temporal and mediotemporal regions of the brain like with Alzheimer’s disease for instance.

A star-shaped brain cell called an astrocyte appears to help keep blood pressure and blood flow inside the brain on a healthy, even keel, scientists report.

Thanks to advances in brain imaging technology, we now know how specific concrete objects are coded in the brain, to the point where we can identify which object, such as a house or a banana, someone is thinking about from its brain activation signature.

A new study finds some people can be trained to learn absolute pitch.

Scientists have discovered a previously unknown link between the brain and the immune system that could help explain links between poor physical health and brain disorders including Alzheimer’s and depression.

A team of neuroscientists has determined how a pair of growth factor molecules contributes to long-term memory formation, a finding that appears in the journal Neuron.

Our understanding of how a key part of the human brain works may be wrong. That’s the conclusion of a team at Oxford University’s Centre for Human Brain Activity (OHBA), published in journal Trends in Cognitive Sciences. Until now, it was thought that working memory – the way in which we deal with and respond to immediate demands – was underpinned by stable brain patterns. The OHBA team discovered that instead, the areas of the brain responsible for working memory are changing all the time.

A new study finds people with higher levels of moral reasoning have greater gray matter volume in brain regions linked to social behaviour, decision-making and conflict processing, compared with those who have lower levels of moral reasoning.

Genes linked to creativity could increase the risk of developing schizophrenia and bipolar disorder, according to new research.

One of the major challenges of cocaine addiction is the high rate of relapse after periods of withdrawal and abstinence. But new research reveals that changes in our DNA during drug withdrawal may offer promising ways of developing more effective treatments for addiction.

According to a piece of research by the UPV/EHU-University of the Basque Country, the capacity to recall specific facts deteriorates with age, but other types of memory do not.

Finally, this week, a new study has found that the brain shrinks over the course of the day, ending up smaller in the evening – before returning to its full size the next morning.

Weekly Neuroscience Update

March 21, 2015Leave a comment

A research team has used neuroimaging techniques to investigate how being in a romantic relationship produces alterations in the architecture of the brain. They found that being in love is associated with increased connectivity between regions of the brain associated with reward, motivation, emotion regulation, and social cognition.

Research from McGill University reveals that the brain’s motor network helps people remember and recognize music that they have performed in the past better than music they have only heard.

The human brain can select relevant objects from a flood of information and edit out what is irrelevant. It also knows which parts belong to a whole. If, for example, we direct our attention to the doors of a house, the brain will preferentially process its windows, but not the neighbouring houses. Psychologists have now discovered that this also happens when parts of the objects are merely maintained in our memory.

Researchers have found that teens who smoked marijuana daily for several years have an abnormally shaped hippocampus and do poorly on tasks involving long-term memory.

A new study has shown how intentional recall is beyond a simple reawakening of a memory; and actually leads us to forget other competing experiences that interfere with retrieval.

Researchers have identified key cells within the brain that are critical for determining circadian rhythms, the 24-hour processes that control sleep and wake cycles, as well as other important body functions such as hormone production, metabolism, and blood pressure

New York University researchers have devised a computer model to explain how a neural circuit learns to classify sensory stimuli into discrete categories, such as “car vs. motorcycle.” Their findings, which appear in the journal Nature Communications, shed new light on the brain processes underpinning judgments we make on a daily basis.

Queensland scientists have found that non-invasive ultrasound technology can be used to treat Alzheimer’s disease and restore memory.

Researchers at MIT have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles — a technique allowing direct stimulation of neurons, which could be an effective treatment for a variety of neurological diseases, without the need for implants or external connections.

Researchers have come up with a new way to evaluate how well computers can divine information from images. The team describes its new system as a “visual Turing test,” after the legendary computer scientist Alan Turing’s test of the extent to which computers display human-like intelligence.

Thousands of genetic “dimmer” switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.

Finally this week, a new study finds that giving a drug that changes the neurochemical balance in the brain causes a greater willingness to engage in prosocial behaviors, such as ensuring that resources are divided more equally.

Weekly Neuroscience Update

March 7, 2015Leave a comment

Carnegie Mellon University neuroscientists have identified a new pathway by which several brain areas communicate within the brain’s striatum.

An over-active habit system may be at the root of many psychological problems involving repetitive behaviours like OCD, alcoholism and binge eating, new research suggests. The neuroimaging study, which is published in the American Journal of Psychiatry, found that people with Obsessive-Compulsive Disorder (OCD) had difficulty controlling their habits.

A new study suggests that the right hemisphere of the brain may be able to assist a damaged left hemisphere in protecting visual attention after a stroke.

Computer based ‘brain training’ can boost memory and thinking skills in older adults, but many programs promoted by the $1 billion brain training industry are ineffective, reveals new research by the University of Sydney.

Researchers have found that navigational brain cells that help sense direction are as electrically active during deep sleep as they are during wake time—and have visual and vestibular cues to guide them. Such information could be useful in treating navigational problems, among the first major symptoms of Alzheimer’s disease and other neurological disorders.

New technology could help researchers advance blood biomarker capabilities that show changes in low concentrations of specific proteins present following a neurological injury.

Our brains generate a constant hum of activity: As neurons fire, they produce brain waves that oscillate at different frequencies. Long thought to be merely a byproduct of neuron activity, recent studies suggest that these waves may play a critical role in communication between different parts of the brain.

People with anorexia nervosa and with body dysmorphic disorder have similar abnormalities in their brains that affect their ability to process visual information, a new study reveals.

Finally this week, overall fluid intelligence — the ability to analyze information, engage in critical thinking, and solve problems — is thought to peak in early adulthood, but a new study suggests that different aspects of fluid intelligence peak at different ages.