Tag: neuroscience research

Slow brain waves play key role in coordinating complex activity

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UCSF neurosurgeons place 64-electrode grids on the surface of the brain's temporal and frontal lobes to locate regions where epileptic seizures originate. These grids allowed UC Berkeley neuroscientists to study the interaction of brain waves during simple tasks, such as word recognition or hand movements. (Images courtesy the Knight Lab)

UCSF neurosurgeons place 64-electrode grids on the surface of the brain’s temporal and frontal lobes to locate regions where epileptic seizures originate. These grids allowed UC Berkeley neuroscientists to study the interaction of brain waves during simple tasks, such as word recognition or hand movements. (Images courtesy the Knight Lab)

While it is widely accepted that the output of nerve cells carries information between regions of the brain, it’s a big mystery how widely separated regions of the cortex involving billions of cells are linked together to coordinate complex activity. Now a new study by neuroscientists at the University of California, Berkeley, and neurosurgeons and neurologists at UC San Francisco (UCSF) is beginning to answer that question.

“One of the most important questions in neuroscience is: How do areas of the brain communicate?” said Dr. Robert Knight, professor of psychology, Evan Rauch Professor of Neuroscience and director of the Helen Wills Neuroscience Institute at UC Berkeley. “A simple activity like responding to a question involves areas all over the brain that hear the sound, analyze it, extract the relevant information, formulate a response, and then coordinate your lips and mouth to speak. We have no idea how information moves between these areas.”

By measuring electrical activity in the brains of pre-surgical epilepsy patients, the researchers have found the first evidence that slow brain oscillations, or theta waves, “tune in” the fast brain oscillations called high-gamma waves that signal the transmission of information between different areas of the brain. In this way, the researchers argue, areas like the auditory cortex and frontal cortex, separated by several inches in the cerebral cortex, can coordinate activity.

“If you are reading something, language areas oscillate in theta frequency allowing high-gamma-related neural activity in individual neurons to transmit information,” said Knight. “When you stop reading and begin to type, theta rhythms oscillate in motor structures, allowing you to plan and execute your motor response by way of high gamma. Simple, but effective.”

The findings are reported in the Sept. 15 issue of Science.

Read more at UC Berkeley News

Weekly Neuroscience Update

sad music

Sad music might actually evoke positive emotions reveals a new study by Japanese researchers. The findings help to explain why people enjoy listening to sad music, say Ai Kawakami and colleagues from Tokyo University of the Arts and the RIKEN Brain Science Institute, Japan.

Extroverts may be more outgoing and cheerful in part because of their brain chemistry, reports a study by Cornell neuroscientists.

Researchers at Neuroscience Research Australia (NeuRA) have discovered that the region of the brain called the orbitofrontal cortex plays a key role in linking emotion and memories. The finding comes from a new study, which demonstrates that patients with frontotemporal dementia (FTD) lose the “emotional content” of their memories.

Researchers in Oxford have demonstrated a significant improvement in the treatment of advanced Parkinson’s disease with deep brain stimulation.

In a study examining how bilingual children learn the two different sound systems of languages they are acquiring simultaneously, researchers have discovered insights that indicate children can learn two native languages as easily as they can learn one.

Scientists have developed a method with which the chances of success of a surgical procedure for temporal lobe epilepsy can be accurately predicted.

Weekly Neuroscience Update

When sound waves hit a sensory cell of the ear, they are converted into electrical nerve signals through specialized ion channels that open and close. Scientists at the University of Göttingen have now discovered a protein that is essential for the opening and closing of these ion channels. The protein could thus be responsible for the ability to hear.

High baseline levels of neuronal activity in the best connected parts of the brain may play an important role in the development of Alzheimer’s disease.

A team of researchers have developed a multidimensional set of brain measurements that, when taken together, can accurately assess a child’s age with 92 percent accuracy.

A mysterious region deep in the human brain could be where we sort through the onslaught of stimuli from the outside world and focus on the information most important to our behavior and survival, Princeton University researchers have found.

Weekly Neuroscience Update

Recent cough research, highlighted in a feature at ScienceNews, suggests that the neural circuitry of coughing also involves temperature perception and higher brain areas.

Research undertaken at UCLA, used MRI scans to compare the brains of 50 meditators to 50 non-meditators. What they discovered was that long-term meditators display large amounts of gyrification in the brain (the amount of folding in the cortex) which is what gives the brain its unique, ridged appearance. The folded a brain is, the quicker it can process information.

Anxious people have a heightened sense of smell when it comes to sniffing out a threat, according to a new study by Elizabeth Krusemark and Wen Li from the University of Wisconsin-Madison in the US.

Nerve cells from the brain’s emotion hub talk directly to a region that doles out attention, a new study shows. The connection, described in the April 11 Journal of Neuroscience, may help explain how people automatically focus on emotional events.

Nerve cells from the brain’s emotion hub talk directly to a region that doles out attention, a study of monkeys shows. The connection, described in the April 11 Journal of Neuroscience, may help explain how people automatically focus on emotional events.

University of Illinois scientists have mapped the physical architecture of intelligence in the brain in one of the largest and most comprehensive analyses so far of the brain structures vital to general intelligence and to specific aspects of intellectual functioning, such as verbal comprehension and working memory.Theirs is one of the largest and most comprehensive analyses so far of the brain structures vital to general intelligence and to specific aspects of intellectual functioning, such as verbal comprehension and working memory.

Weekly Round-Up

Blogging may have psychological benefits for teens suffering from social anxiety, improving their self-esteem and helping them relate better to their friends, according to new research published by the American Psychological Association.

Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects. The findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly.

Deep depression that fails to respond to any other form of therapy can be moderated or reversed by stimulation of areas deep inside the brain.

Radiology researchers at The University of Texas Health Science Center at Houston (UTHealth) have found evidence that multiple sclerosis affects an area of the brain that controls cognitive, sensory and motor functioning apart from the disabling damage caused by the disease’s visible lesions.

People with diets high in several vitamins or in omega 3 fatty acids are less likely to have the brain shrinkage associated with Alzheimer’s disease than people whose diets are not high in those nutrients, according to a new study published in the December 28, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

When you experience a new event, your brain encodes a memory of it by altering the connections between neurons. This requires turning on many genes in those neurons. Now, MIT neuroscientists have identified what may be a master gene that controls this complex process. The findings, described in the Dec. 23 issue of Science, not only reveal some of the molecular underpinnings of memory formation — they may also help neuroscientists pinpoint the exact locations of memories in the brain.

Inside the gaming brain

In this recent lecture, I translate cutting-edge neuroscience to answer such questions as how a gamers brain is ‘formed’ and illuminate the brain processes involved in generating creative games and using them to get the best from the brain.

Weekly Round Up

The Guardian newspaper reports on a new study on how video games can persist in our perception as fleeting hallucinations in an effect labelled ‘game transfer phenomena’.

Responding to faces is a critical tool for social interactions between humans. Without the ability to read faces and their expressions, it would be hard to tell friends from strangers upon first glance, let alone a sad person from a happy one. Now, neuroscientists from the California Institute of Technology (Caltech), with the help of collaborators at Huntington Memorial Hospital and Cedars-Sinai Medical Center, have discovered a novel response to human faces by looking at recordings from brain cells in neurosurgical patients.

New medical research tends to confirm that the human brain does not stop developing in adolescence, but continues well into our 20s, according to investigators at the University of Alberta.

A review of the evidence to date suggests that music therapy can help patients recover their movements after experiencing brain damage.

Frontotemporal dementia—triggered by cell death in the front and sides of the brain—accounts for about one-fourth of all cases of early-onset dementia. Now, scientists at UCLA have discovered that a certain signaling pathway plays a key role in the brain disorder and may offer a potential target for treatment.

Finally, the latest research shows that your learning can continue even while you sleep, so those adverts for products that help you learn while you sleep may be true after all!

Treatment expectation will boost or reduce drug efficacy

If you read my post yesterday on the neuroscience of success, you will have read of the unbeatable combination of optimism tempered with reality. Having written that post, it was fascinating today to read a paper in the current edition of Science Translational Medicine, which shows that a patient’s belief that a drug will not work can indeed become a self-fulfilling prophecy.

Researchers from Oxford University identified the regions of the brain which are affected in an experiment where they applied heat to the legs of 22 patients, who were asked to report the level of pain on a scale of one to 100. The patients were also attached to an intravenous drip so drugs could be administered secretly.

The initial average pain rating was 66. Patients were then given a potent painkiller, remifentanil, without their knowledge and the pain score went down to 55.

They were then told they were being given a painkiller and the score went down to 39.

Then, without changing the dose, the patients were then told the painkiller had been withdrawn and to expect pain, and the score went up to 64.

So even though the patients were being given remifentanil, they were reporting the same level of pain as when they were getting no drugs at all.

Brain scans during the experiment also showed which regions of the brain were affected. The expectation of positive treatment was associated with activity in the cingulo-frontal and subcortical brain areas while the negative expectation led to increased activity in the hippocampus and the medial frontal cortex.

The limbic system comprises several cortical and subcortical brain areas that are interconnected. This system essentially controls emotions, and the autonomic and endocrine responses associated with emotions. The hippocampus also belongs to the limbic system and plays an important role in long-term memory. Activity in the medial frontal cortex predicts learning from errors.

This latest research could have important consequences for patient care and for testing new drugs. Negative expectations about a drug can reduce its efficacy quite significantly, as indeed positive expectation can boost its efficacy. So it seems, that once more, a positive attitude holds the key to another area of success!

Weekly Round-Up

 

fightclub

Does a part of our brain host its own fight club?

In this week’s round-up of the latest discoveries and research in the field of neuroscience – the science of falling in love, the brain’s own fight club and how blogging may hold the secret of making boys write properly.

Continuing with the Valentine’s theme this week, Judy Foreman examines the scientific basis of falling in love.

In the Feb. 10 online issue of Current Biology, a Johns Hopkins team led by neuroscientists Ed Connor and Kechen Zhang describes what appears to be the next step in understanding how the brain compresses visual information down to the essentials.

In Itching for a Fight Science News carries the story that a small part of our brain hosts its very own fight club.

And finally, a report in The Independent newspaper on how blogging may have solved one of the most pressing problems that has perplexed the education world for years: how to get boys to write properly.