Weekly Neuroscience Update

 Credit: Radiological Society of North America

Low-level light therapy appears to affect healing in the brains of people who suffered significant brain injuries, according to a study published in Radiology.

An international team of clinicians and neuroscientists has published a new perspective on the process of neurodegeneration. Their findings review evidence for a mechanism upstream of amyloid including the key neurochemical driving this process.

A new study reveals the brain mechanisms behind speech impairment in Parkinson’s disease.

Researchers designed and implanted a transparent window in the skull of a patient, then used functional ultrasound imaging to collect high-resolution brain imaging data through the window. Their preliminary findings, published in Science Translational Medicine, suggest that this sensitive, non-invasive approach could open new avenues for patient monitoring and clinical research, as well as broader studies of how the brain functions.

New research finds that reports of cognitive decline from patients and their partners are linked to the accumulation of tau tangles, a hallmark of Alzheimer’s disease.

A new study finds a link between a diet high in ultra-processed foods and an increased risk of cognitive impairment and stroke. This association was particularly pronounced among Black participants. While more research is needed, the findings highlight the potential impact of food processing on brain health.

New research has found a distinct relationship between sleep duration, social media usage, and brain activation across brain regions that are key for executive control and reward processing.

For patients with chronic migraine, nerve decompression surgery effectively reduces the number of headache days—the outcome measure preferred by neurologists—along with other measures including the frequency and intensity of migraine attacks, reports a study in the June issue of Plastic and Reconstructive Surgery.

A new study uncovers a key biological process targeted by SSRIs, suggesting new clinical applications.

Researchers have reported that patients with Parkinson’s disease exhibiting sympathetic denervation in the major salivary glands and the heart tend to have more advanced non-motor symptoms as they age, suggesting that age plays an important role in disease progression.

An international study, published in Nature Communications, may facilitate the creation of new personalized treatments for people diagnosed with schizophrenia. 

A World Health Organization-commissioned systematic review finds that radio wave exposure from mobile phones does not affect learning, memory, attention span and other cognitive functions like coordination.

Researchers have leveraged the power of artificial intelligence analytical models to match a patient’s medical history to the most effective antidepressant, allowing patients to find symptom relief sooner.

A new study finds a strong association between teen cannabis use and a significantly increased risk of developing psychotic disorders. This risk appears to be age-dependent, with adolescents being particularly vulnerable to the effects of cannabis on their developing brains. While further research is needed, these findings raise concerns about early cannabis use and highlight the importance of prevention strategies.

Does sleep clear more toxins from the brain than when we’re awake? The latest research casts doubt on the theory.

A new study finds that urolithin A, a substance found in pomegranates, can improve memory and may help treat Alzheimer’s disease. This natural compound works by removing damaged mitochondria from the brain, similar to the effects of NAD supplements. While dosage is still being determined, this discovery offers promising potential for treating and preventing neurodegenerative diseases.

Finally this week, our willingness to help others is governed by a specific brain region pinpointed by researchers in a study of patients with brain damage to that region.

Weekly Neuroscience Update

Vertex-wise comparisons between ADHD (N = 60) and controls (N = 23), and between ADHD responders (N = 42) and non-responders (N = 18). Credit: Nature Mental Health (2024).

New research has found that the effectiveness of ADHD medication may be associated with an individual’s neuroanatomy.

Although there are still some aspects pending confirmation for its use in the clinical setting, and its resolution needs to be improved slightly, a new study has shown that a method routinely used to carry out ophthalmological tests can also be used to monitor the neurodegeneration that occurs in Parkinson’s patients.

Scientists have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing systems.

New research has identified a specific pattern of autoantibodies in the blood that precedes the clinical onset of multiple sclerosis (MS), potentially paving the way for early diagnosis and treatment. Their study found that 10% of MS patients displayed a unique set of autoantibodies against both human proteins and common pathogens like the Epstein-Barr Virus years before showing symptoms.

Researchers have identified a promising new approach to treating persistent neurological symptoms associated with Lyme disease.

A new study investigates why everyday actions like locking a door are often forgotten. The study revealed that while emotionally charged or unique events are initially memorable, even these can fade within 24 hours, particularly positive experiences. This research provides insight into the selective nature of memory and suggests that our brains prioritize and even forget information to manage cognitive load.

Managing a stroke patient’s blood sugar levels after they receive powerful clot-busting drugs might help them survive their health crisis, a new trial finds.

Researchers have created a thin film that combines an electrode grid and LEDs that can both track and produce a visual representation of the brain’s activity in real time during surgery. The device is designed to provide neurosurgeons with visual information about a patient’s brain to monitor brain states during surgical interventions to remove brain lesions including tumors and epileptic tissue.

A new study identifies a new metric for diagnosing autism.

New research has found a significant association between participating in low to moderate intensity exercise and reduced rates of depression.  However, this was not strongly observed for high-intensity exercise. Physical activity was also significantly associated with reduced risk of severe mental health conditions, including a reduction in psychosis/schizophrenia by 27%.

An international collaborative research team has discovered a novel mechanism underlying memory involving rapid changes in a specific DNA structure.

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a study published in the online issue of Neurology Clinical Practice

Finally this week, new research has highlighted the profound link between dietary choices and brain health.

Weekly Neuroscience Update

Smaller Left vmPFC was associated with future smoking. Credit: Nature Communications (2023)

Levels of gray matter in two parts of the brain may be linked to a desire to start smoking during adolescence and the strengthening of nicotine addiction, a new study has shown.

Researchers have enabled machine learning to accurately predict Parkinson’s disease subtypes using stem cell images. This breakthrough showcases computer models classifying four Parkinson’s subtypes, with top accuracies reaching 95%. This could revolutionize personalized medicine and aid in more targeted drug research for Parkinson’s.

A large international team of medical researchers has found that the severity of COVID-19 infections in children over the course of the pandemic varied by age and viral variant.

Researchers have illuminated how our brain maintains focus amidst distractions. Their study identifies “visual-movement” neurons in the lateral prefrontal cortex (LPFC) that use coordinated activity called “beta bursts” to suppress distracting stimuli and ensure attention remains on rewarding tasks. This discovery gives a deeper understanding of cognitive focus and offers insights into disorders like ADD and OCD.

More cases of children born with abnormal brain development may have genetic explanations than previously thought, according to a recent study published in JAMA Neurology.

Hearing impairment may cause difficulties in social interactions, but new research indicates that social struggles experienced by deaf individuals are likely not due to brain alterations, but rather due to non-supportive environments.

Scientists have identified a series of processes that help the brain adapt to damage caused by breakdowns in circuits that govern movement, cognition and sensory perception.

For the first time, researchers have discovered that the ventral tegmental area (VTA) of the brain—a key structure involved in motivation and reward appreciation—has altered connectivity patterns with specific brain regions in patients with obesity. Individuals with obesity have hyper-connectivity of the VTA with part of the ventral occipitotemporal cortex (visual processing for food images) and hypo-connectivity with the left inferior frontal gyrus (associated with cognitive control), according to a new study in Obesity.

Researchers have identified a key pathway, involved in inflammation, which appears to be activated in people with long COVID who have symptoms of “brain fog.”

Using a novel approach of precision neuroimaging and high-resolution functional magnetic resonance imaging (fMRI), a team of neuroscientists and physicists have discovered previously unknown cortical networks and shed light on the anatomical organization of the human memory system.

A pioneering scientific study has shown that the effects of multiple concussions in rugby players continue to have an impact on their brain even in retirement. 

Researchers have coupled the measurements of brain waves associated with disorders of consciousness (DoC) with glucose usage in specific brain areas, identifying where in the brain the waves might be generated.

A new study shows that brains with Alzheimer’s disease have subnormal levels of important dietary antioxidants.

A breakthrough project mapping brain changes in nearly 1,300 people diagnosed with six different types of mental illness has revealed the extraordinary diversity of brain changes found in people with conditions like major depression and schizophrenia.

Researchers have unveiled a promising link between adult education and reduced dementia risk. 

Neuroscientists have shown that adversities permanently change the functioning of the brain. Furthermore, an aberrant reaction of the brain to adversities is related to anxiety symptoms. This may have predictive value for the development of psychiatric disorders.

Finally this week, a new study identifies sex differences in the brain cell types responding to stress.

Weekly Neuroscience Update

Factors associated with healthy aging in Latin American populations. Credit: Nature Medicine (2023)

Researchers at Trinity College Dublin studying the factors influencing healthy brain aging in Latin American and Caribbean (LAC) countries find the lessons learned there, can also be applied to home.

Immune cells in the brains of people who had Alzheimer’s disease appear to behave differently than those who had healthy brains for their age, according to an analysis of the cells’ gene activity. The finding suggests it might be possible to treat Alzheimer’s disease by altering the behavior of these cells.

The longer a person has type 2 diabetes, the more likely they may be to experience changes in brain structure, a new study finds.

Using human “mini-brain” models known as organoids, scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions. The specific cells are known as excitatory cortical neurons.

Psilocybin, the active ingredient in psychedelic mushrooms, shows promise for the transitional treatment of episodic migraines in early clinical trials, according to a recent review.

Researchers have discovered that a neural marker of error detection in the brain’s visual system previously considered pre-attentive may actually require attention and that subtle visual irregularities may be revealed by other neural markers.

A new study has demonstrated that self-organization of neurons as they learn follows a mathematical theory called the free energy principle.

The neural network related to speech is mostly located in the left cerebral hemisphere, while singing has been primarily associated with the structures of both hemispheres. However, a new study indicates that the left hemisphere has a greater significance, including in terms of singing, than previously thought.

A new digital headset designed to measure alterations in brain function could change decisions about how quickly an athlete is ready to return to play after a concussion.

A new study suggests stimulating the sense of smell can boost memory. Older adults exposed to odors while they slept performed better on verbal memory tests and showed improved function in a brain pathway that supports memory formation, according to the study, published in the journal Frontiers in Neuroscience.

Finally this week, researchers have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells.

Anatomy Of A Migraine Attack #BrainAwarenessWeek

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Scientists have learned a lot in recent years about what happens in the brain to explain the throbbing pain, nausea, heightened sensitivity to light or sound felt during a migraine headache and the mysterious ‘aura’ that both doctors and scientists use to describe the telltale period, starting up to an hour before a migraine attack, when a person sees dots, wavy lines, flashing lights, blind spots or difficulty with speech, sensation, or movement.

What triggers a migraine attack? 

Although researchers don’t understand exactly what triggers migraine attacks, they do know that certain foods, lack of sleep, changes in weather, and even stress can trigger a migraine attack in 1 in 200 people.

The anatomy of a migraine attack

Neuroscientists now see migraine as firstly a disturbance in nerve function rather than a disorder of the brain’s blood vessels. It is believed that in most patients, a wave of electrical activity passing through a major nerve that collects and transmits signals to the face – the trigeminal nerve – and stimulates the release of chemicals such as CGRP and other substances that cause inflammation, makes the nerves more sensitive to pain, and causes blood vessels near the brain to expand (dilate). This nerve irritation often progresses as an electrical wave from the skin to nerves located centrally in the brain.

The key to treatment is to act quickly to stop the irritation spreading.  In fact, anti-migraine drugs can offer relief only in the earlier stages of the attack, but not later, when the pain neurons in the brain have become sensitized. For this reason, patients are advised to take medication within 20 minutes of an attack and while migraine pain is still mild.

The wave that turns into a flood

A migraine attack is triggered when a wave of electrical activity that starts in the trigeminal nerve on the side of the face enters the brain and ripples across the surface of the brain. In fact, researchers have been able to demonstrate a possible link between this wave and the experience of ‘aura’ particularly as it spreads across the visual part of the brain. Several drugs used to prevent migraine attacks work by preventing this wave from spreading.

 


Notes

Migraine is a complex neurological condition that is classified by the World Health Organisation as the 7th most disabling disease worldwide, the 4th for women.

Migraine is the most common neurological condition in the world, affecting about 12 – 15% of people. It is three times more common in women than it is in men and is usually inherited. It is a very individual condition. Some people experience only one or two attacks per year while others suffer on a weekly basis. An attack can last from 4 to 72 hours.

For more information and support visit https://migraine.ie

Weekly Neuroscience Update

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MIT engineers have developed a technique that allows them to rapidly image many different proteins within a synapse.

A new rapid imaging technique allows researchers to view synaptic proteins at high resolution.

There may be some good news for people with vestibular migraine, a type of migraine that causes vertigo and dizziness with or without headache pain. A small, preliminary study suggests that non-invasive nerve stimulation may show promise as a treatment for vestibular migraine attacks, a condition for which there are currently no approved treatments.

New research uses artificial intelligence to identify patterns of brain activity that make people less responsive to certain antidepressants.

A new study challenges the belief that epileptic seizures can be predicted by brain wave patterns. Researchers report they have found no evidence that specific brain wave patterns can be a predictive indicator of seizure onset.

New research shows prepartum and postpartum physical and mental health was associated with persistent severe sleep problems in their babies.

In a first-of-its-kind study, researchers have pieced together a road map of typical brain development in children during a critical window of maturation. The study shows how a “wave of brain maturation” directly underlies important social and behavioral changes children develop during the transition from childhood to adolescence.

Finally, this week, a new study highlights the role estrogen plays in the differences in the progression of Parkinson’s disease between men and women.

Weekly Neuroscience Update

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Image Credit: Guillaume Sandoz, CNRS

Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on Dec. 17, 2018, open a new path for the development of anti-migraine medicines.

Scientists using eye tracking software, report what we look at helps guide our decisions when faced with two visible choices.

A new study reports children and teens who face chronic bullying have altered brain structure, as well as problems with anxiety and depression. Researchers found those who were bullies had structural changes to the putamen and caudate, contributing to the development of anxiety related behaviors and emotional processing.

Researchers have identified specific neurons in the medial prefrontal cortex, called self-monitoring error neurons, that fire immediately after people make a mistake.

New findings show how alcohol influences dopaminergic and inhibitory neurons in the ventral tegmental area. The findings could help develop new treatments for alcohol dependence.

A diet of fast food, cakes and processed meat increases your risk of depression, according to a new study.

Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases.

A new study reports lightly stroking an infant, at a speed of 3 centimeters per second, can help to provide pain relief prior to medical procedures.

Researchers have identified cognitive subgroups related to genetic differences in Alzheimer’s patients. The findings could open the door for more personalized treatments of the neurodegenerative disease.

A previously unknown brain mechanism that regulates anxiety has come to light. It allows a gene-altering protein to enter the nucleus of brain cells.

Finally this week, researchers discovered activity in brain regions involved in reward response from dopamine was higher in subjects injected with the hormone ghrelin, but only when responding to images associated with food smells. The study reports ghrelin controls the extent to which the brain associates reward with food odors.

 

 

Weekly Neuroscience Update

guitar-869217_960_720.jpgResearchers say those who can improvise are better musicians than those who have limited improvisational experience.

Melatonin is a hormone known to promote sleep, but its underlying mechanisms are unknown. Now, researchers have discovered how melatonin suppresses neurons in the brain that keeps you awake and alert. These findings could lead to new therapies for those who suffer from insomnia.

A new study shows how specific neurons can process sensory information about temperature and facilitate a change in behavior to adapt to the climate.

Researchers have identified electrical activity in the brain that is specific to the start of migraines. The new study reports spreading depolarization can be seen as a migraine begins, and an electrical current can be used to stop it in its tracks.

Adolescent drinking is associated with changes in the metabolite profile, a new study shows. 

Scientists are using big data and artificial intelligence to map neural networks in the brain. The new technology could help to better understand the progression of neurodegenerative diseases.

Sound and object motion can be used to change perceptions about body size, according to a new study.

Researchers report impairments in the neuroprotective communication between neural blood vessels, astrocytes and neurons may be an early factor in how high blood pressure may impair cognitive function.

A new study confirms a link between a number of autoimmune diseases and an increased risk of developing psychosis.

Autonomous Sensory Meridian Response (ASMR) – the relaxing ‘brain tingles’ experienced by some people in response to specific triggers, such as whispering, tapping and slow hand movements – may have benefits for both mental and physical health, according to new research.

Researchers have developed new neural implants that enable targeted delivery of drugs deep into brain structures.

A new study reports specific alterations in signaling circuits associated with memory can induce an abnormal response in neurons, which is linked to the aging process and cognitive decline.

Researchers say the combination of low muscle mass and strength in the context of high-fat mass, could be a predictor of cognitive function in older adults. 

Obstructive sleep apnoea (OSA) is associated with changes to the structure of the brain that are also seen in the early stages of dementia, according to a study published in the European Respiratory Journal.

Finally, this week, a new study reports a mother’s diet during pregnancy may have an effect on the composition of her child’s gut bacteria. 

 

 

Weekly Neuroscience Update

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AI research has come full circle, helping neuroscientist better understand how the human brain works, researchers say.

Babies removed from their mothers for 24 hours when they were 9 days old exhibited significant behavioral and brain structural abnormalities in adulthood, a new study reports. Researchers noted memory impairment and less communication between specific brain regions in those removed from maternal care.

Researchers have identified three genes linked to hemiplegic migraine.

People whose negative emotional responses to stress carry over to the following day are more likely to report health problems and physical limitations later in life compared with peers who are able to “let it go,” according to findings published in Psychological Science.

Using electrical fields to simulate slow wave sleep, researchers enhance memory.

A new study has identified a link between visual processing problems and an increased risk of developing a mental health disorder. The study reports the risk for mental illness increases when the visual cortex has difficulty communicating with networks associated with focus and introspection.

The superior size and complexity of the human brain compared to other mammals may actually originate from fewer initial starting materials, new research has suggested.

According to researchers, dopamine neurons may play a key role in the formation of episodic memory. The findings could help in the development of new treatments for neurodegenerative disorders that affect memory.

A new study reveals up to 25% of rhythmic genes lose their biological rhythm following a 4-day night shift simulation.

Damage to some of the pathways that carry information throughout the brain may be responsible for attention deficit in patients who have had a subcortical stroke in the brain’s right hemisphere, according to a study published online in the journal Radiology. Researchers hope the findings may provide a measure for selecting suitable patients for early interventions aimed at reducing cognitive decline following a stroke.

Finally this week, a new machine learning study has revealed a novel combination of factors that can increase a person’s risk of developing dementia.