Weekly Neuroscience Update

The Brain Connectivity Model of Intelligence. Schematic illustration of selected brain connections that have been linked to intelligence differences across studies. Adapted from Hilger & Sporns, 2021. Credit: Thiele et al.

Neuroscientists have developed machine learning models to predict human intelligence.

Researchers have found that incorporating specific nutrients into a regular diet may reduce iron buildup in the brain—a factor associated with cognitive decline in normal aging. The research team said the findings offer valuable insights for future clinical trials aimed at evaluating the impact of similar nutritional intake on brain iron accumulation and cognitive function.

The short-term boost our brains get after we do exercise persists throughout the following day, suggests a study led by UCL (University College London) researchers.

Thirteen proteins linked to brain aging in humans are identified in a Nature Aging paper. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old in humans, and suggest that these ages may be important for potential interventions in the brain aging process.

Brain scans show vulnerability to gaming addiction in teens.

A team of scientists has uncovered a novel mechanism that reshapes our understanding of how blood flow is regulated in the brain. The study, published in The Proceedings of the National Academy of Sciences introduces Electro-Calcium (E-Ca) Coupling, a process that integrates electrical and calcium signaling in brain capillaries to ensure precise blood flow delivery to active neurons.

Researchers at the Yale School of Medicine found structural and functional alterations in specific brain regions of individuals with opioid use disorder. The study’s results were published in Radiology.

A new study has identified a unique brain network that links varied patterns of brain atrophy, or shrinkage, associated with schizophrenia. By combining neuroimaging data from multiple studies involving more than 8,000 participants, the research team found a specific connectivity pattern of atrophy that was present across different stages and symptoms of schizophrenia—and distinct from brain networks associated with other psychiatric disorders.

New research provides valuable insights into the brain-body immune connection, identifying key communication hubs in the dural sinuses and skull bone marrow at the back of the head.

New research shows that slow-wave sleep strengthens synaptic connections in the neocortex, making it more receptive to long-term memory formation. Researchers found that during deep sleep, synapses in the neocortex reach peak efficiency at precise moments within slow-wave oscillations.

A new study suggests how brain, with sleep, learns meaningful maps of spaces.

A large-scale study revealed that genetic variants linked to dyslexia are associated with differences in brain areas controlling motor coordination, vision, and language. Using data from over a million individuals, researchers calculated genetic “polygenic scores” for dyslexia and analyzed their relationship to brain structures. Higher genetic risk for dyslexia was tied to lower volumes in brain regions related to speech processing and movement, and increased volumes in the visual cortex. Differences in the brain’s internal capsule, which connects regions, were also observed.

Cognitive impairment, especially in learning and memory, is more likely among people with epilepsy, according to a newly published study.

A recent study explores how connections across the entire brain predict human intelligence, moving beyond traditional focus on specific brain areas like the prefrontal cortex. Using fMRI data from over 800 individuals, researchers analyzed communication between brain regions to predict fluid, crystallized, and general intelligence scores. Findings reveal that distributed brain-wide connections play a crucial role, surpassing existing models that emphasize localized regions. This research highlights intelligence as a global property of the brain, offering fresh perspectives for understanding cognitive processes.

The chromosomal disorder 22q11.2 deletion syndrome (22q) has emerged as one of the strongest risks for schizophrenia.

New research reveals that brain structure varies with reading ability, particularly in the left hemisphere. Better readers have distinct traits, including a larger anterior temporal lobe for integrating word meaning and a thicker left Heschl’s gyrus for phonological processing.

Night shifts and poor sleep quality are associated with an increased risk for incident epilepsy, according to a study published in BMC Public Health.

People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial.

Finally this week, researchers have found a relationship between lifestyle choices that affect dementia risk and early signs of aging in the brain.

Weekly Neuroscience Update

(A) Brain regions where spectra were measured (yellow box) (B) 1H MR spectrum in the hippocampus: Hippocampal taurine signal shown at 3.4 ppm (arrow). Black line: actual measured spectrum. Red line: LCModel fitting spectrum. Credit: Korea Basic Science Institute (KBSI)

For the first time, a research team in Korea has discovered there is a significant relationship between depression and the taurine concentration in the hippocampus, an area of the brain responsible for memory and learning functions. This discovery provides the opportunity to publicize the role and importance of taurine in future prevention, diagnosis, and treatment of depression.

A recent study reveals that individuals who experienced childhood adversity, such as neglect or abuse, faced higher chances of COVID-19 hospitalization or mortality in adulthood.

Time spent watching television or playing computer games has measurable and long-term effects on children’s brain function, according to a review of 23 years of neuroimaging research, which—while showing negative impacts—also demonstrates some positive effects.

A first-of-its-kind study has identified overactive inflammation and loss of critical protection mechanisms in the brain as potential contributors to suicide risk.

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development. By incorporating microglia into lab-grown brain organoids, scientists were able mimic the complex environment within the developing human brain to understand how microglia influence brain cell growth and development.

A novel study finds a link between childhood physical fitness and cerebellar grey matter volume in adolescents.

Mayo Clinic researchers have identified new scoring criteria allowing for the detection of treatable forms of rapidly progressive dementia (RPD) with reasonably high confidence during a patient’s first clinical visit. This scoring criteria may allow physicians to substantially reduce the time it takes to begin treatment. The findings are published in the Annals of Neurology.

A new sudy has identified the top three genes responsible for traumatic brain injury complications.

Researchers have made a discovery that sheds light on how our brain cells manage to efficiently replace older proteins. This process is crucial for maintaining effective neural communication and ensuring optimal cognitive function.

A pair of studies has uncovered novel cellular mechanisms that are involved in two types of genetic amyotrophic lateral sclerosis, or ALS.

In a study published in the Journal of Neuroscience Research, psychological assessments indicated that people who regularly use cannabis, or marijuana, tend to have a greater understanding of the emotions of others. Brain imaging tests also revealed that cannabis users’ anterior cingulate—a region generally affected by cannabis use and related to empathy—had stronger connectivity with brain regions related to sensing the emotional states of others within one’s own body.

Finally this week, researchers have unearthed the genetic connection between the heart and brain related to fainting spells.