Weekly Neuroscience Update

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When selecting a video game to play, opting to turn on your Wii may provide a different experience than playing your Xbox, according to a study from Mississippi State University.

Excessive alcohol use accounts for 4% of the global burden of disease, and binge drinking particularly is becoming an increasing health issue. A new review article published Cortex highlights the significant changes in brain function and structure that can be caused by alcohol misuse in young people.

Working with patients with electrodes implanted in their brains, researchers have shown for the first time that areas of the brain work together at the same time to recall memories. The unique approach promises new insights into how we remember details of time and place.

Researchers at the University of Glasgow are hoping to help victims of stroke to overcome physical disabilities by helping their brains to ‘rewire’ themselves.

Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown.

Neuroscientists have released the results of a new study that examines how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.

Neuroscience researchers from Tufts University have found that our star-shaped brain cells, called astrocytes, may be responsible for the rapid improvement in mood in depressed patients after acute sleep deprivation. This in vivo study, published in the current issue ofTranslational Psychiatry, identified how astrocytes regulate a neurotransmitter involved in sleep. The researchers report that the findings may help lead to the development of effective and fast-acting drugs to treat depression, particularly in psychiatric emergencies.

UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus – which provides short-term storage for memories – to the prefrontal cortex’s longer term “hard drive.”

Researchers have found altered connectivity in the brain network for body perception in people with anorexia: The weaker the connection, the greater the misjudgement of body shape.

A group of scientists planning to map all the major connections in the human brain began studying their first test subjects in August. The $30 million Human Connectome Project will trace the main neural pathways that link the roughly 500 major regions in the brain, illuminating how biological circuitry underlies our mental functions. MRI scans of 1,200 people, including 300 pairs of twins, will be used to compile an atlas of communication routes throughout the brain. The resulting blueprint will also reveal how brain connectivity varies from person to person.

How to increase serotonin in the brain without drugs

Aerobic exercise has been shown to elevate mood

As a follow-on to my last post on depression, I would like to direct you to an article I have stumbled upon from the Journal of Psychiatry and Neuroscience (1) published in 2007.

Its primary focus is on individuals with a serotonin-related susceptibility to depression, and nonpharmacologic methods of increasing serotonin to prevent depression in those with such a susceptibility.

Nonpharmacologic methods of raising brain serotonin may not only improve mood and social functioning of healthy people — a worthwhile objective even without additional considerations — but would also make it possible to test the idea that increases in brain serotonin may help protect against the onset of various mental and physical disorders.

The article discusses four possible strategies that are worth further investigation:

1. Altering Thought Patterns

The idea that alterations in thought, either self-induced or due to psychotherapy, can alter brain metabolism is not new. Numerous studies have demonstrated changes in blood flow in such circumstances. However, reports related to specific transmitters are much less common. In one recent study, meditation was reported to increase release of dopamine.The study by Perreau-Linck and colleagues (2) is the first to report that self-induced changes in mood can influence serotonin synthesis.

2. Exposure to Bright Light

Bright light is, of course, a standard treatment for seasonal depression, but a few studies also suggest that it is an effective treatment for nonseasonal depression and also reduces depressed mood in women with premenstrual dysphoric disorder and in pregnant women suffering from depression.

3. Exercise

A third strategy that may raise brain serotonin is exercise. A comprehensive review of the relation between exercise and mood concluded that antidepressant and anxiolytic effects have been clearly demonstrated.

4. Diet

According to some evidence, tryptophan, which increases brain serotonin  is an effective antidepressant in mild-to-moderate depression. Further, in healthy people with high trait irritability, it increases agreeableness, decreases quarrelsomeness and improves mood. However, the idea, common in popular culture, that a high-protein food such as turkey will raise brain tryptophan and serotonin is, unfortunately, false. Another popular myth that is widespread on the Internet is that bananas improve mood because of their serotonin content. Although it is true that bananas contain serotonin, it does not cross the blood–brain barrier.

To read this article in full please click here.

1. J Psychiatry Neurosci. 2007 November; 32(6): 394–399.

2. Perreau-Linck E, Beauregard M, Gravel P, et al. In vivo measurements of brain trapping of α-[11C]methyl-L-tryptophan during acute changes in mood states. J Psychiatry Neurosci 2007;32:430-4.