Weekly Neuroscience Update

Antwwaun Molden, Keith Toston, Julian Standord, Antwon Blake, John ChickIn a small study of former NFL players, about one quarter were found to have “mild cognitive impairment,” or problems with thinking and memory, a rate slightly higher than expected in the general population.

Research at the University of Edinburgh tracked electrical signals in the part of the brain linked to spatial awareness. The study could help us understand how, if we know a room, we can go into it with our eyes shut and find our way around. This is closely related to the way we map out how to get from one place to another.

Scientists have long wondered how nerve cell activity in the brain’s hippocampus, the epicenter for learning and memory, is controlled — too much synaptic communication between neurons can trigger a seizure, and too little impairs information processing, promoting neurodegeneration. Researchers at Georgetown University Medical Center say they now have an answer. In the January 10 issue of Neuron, they report that synapses that link two different groups of nerve cells in the hippocampus serve as a kind of “volume control,” keeping neuronal activity throughout that region at a steady, optimal level.

Seniors who have spoken two languages since childhood are faster than single-language speakers at switching from one task to another, according to a study published in the January 9 issue of The Journal of Neuroscience. Compared to their monolingual peers, lifelong bilinguals also show different patterns of brain activity when making the switch, the study found.

Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells – abundantly found in connective tissues – into functional neurons. The findings, which could have far-reaching implications for the development of new treatments for neurodegenerative diseases like Huntington’s, Parkinson’s and Alzheimer’s, will be published online in advance of the January 17 issue of the journal Cell.

Weekly Neuroscience Update

Loneliness? It’s All a State of Mind

Researchers have found that lonely people have less grey matter in a part of the brain associated with decoding eye gaze and other social cues.

While studying the sense of touch, scientists at Duke Medicine have pinpointed specific neurons that appear to regulate perception.

An international team of researchers has for the first time shown that one area of the brain, called the anterior insular cortex, is the activity center of human empathy, whereas other areas of the brain are not.

Early surgery for patients with slow-growing, low-grade glioma brain tumours may result in better survival than a wait-and-see approach, according to Norwegian research.

Books and educational toys can make a child smarter, but they also influence how the brain grows, according to new research. The findings point to a “sensitive period” early in life during which the developing brain is strongly influenced by environmental factors.

Exercising in your 70s may stop your brain from shrinking and showing the signs of ageing linked to dementia, say experts from Edinburgh University.

A patient’s genetic makeup may explain the “placebo effect,” in which people perceive that a fake treatment makes them feel better, according to a study that may help researchers design better clinical trials. Patients with a certain variation on a gene linked to release of dopamine, a brain chemical that affects emotions and sensations of pleasure and pain, were more likely to respond to a placebo version of acupuncture than patients with a different variation, a study in the journal PLoS One found.

UCLA researchers have for the first time measured the activity of a brain region known to be involved in learning, memory and Alzheimer’s disease during sleep. They discovered that this part of the brain behaves as if it’s remembering something, even under anesthesia, a finding that counters conventional theories about memory consolidation during sleep.

The brains of teenage girls with behavioural disorders are different to those of their peers, UK researchers have found. The Journal of Child Psychology and Psychiatry study of 40 girls revealed differences in the structure of areas linked to empathy and emotions. Previous work has found similar results in boys.

There are two ways we can forget a memory that causes unpleasant sensations, be they a humiliating gaffe at some dinner party or an extremely frightening event, say researchers from the University of Cambridge in the October 17th edition of Neuron.

University of Limerick medical graduates conferred

Pictured with Dr. Neasa Starr at UL Medical Graduation

Last Tuesday, 14 June, was an historic day in the life of the University of Limerick Graduate Entry Medical School  (GEMS) in which I am Foundation Head of Teaching and Research in Physiology.

Four years ago on September 10th we welcomed 32 students, from a variety of degree disciplines, to Limerick to study at Ireland’s first graduate entry medical school. Last week those students, who came from backgrounds as diverse as music, engineering, science, and education, were conferred with their Bachelor of Medicine and Bachelor of Surgery degrees.

Last week’s conferring ceremony for students marks a number of firsts – the first medical school to be founded in Ireland in over 150 years, the first graduate entry medical school in Ireland, and the first to integrate problem based learning techniques into its four-year curriculum.

I join with all my colleagues at GEMS in wishing this cohort of new doctors every success in their future careers.