Easing the pain of migraine attacks

Dr Chad Beyer

Welcome to Part Three of this series on migraine attacks. Today, I am stepping into the world of guest blogging and am delighted to host Inside The Brain’s first guest blogger – Dr Chad Beyer, who explains how the race is on to discover better and safer drugs to diminish migraine pain and prevent future attacks.  

If you belong to the 1 in 4 households in theUnited States or the 11% of the world who suffer from acute migraines, you have about a 50/50 chance of being prescribed a “triptan” or a non-steroidal anti-inflammatory drug (NSAID) such as aspirin.  Unfortunately for patients, both treatment options are routinely accompanied by severe safety liabilities.  Most people are probably aware of the gastrointestinal and cardiovascular side-effects associated with NSAIDs and selective COX-2 inhibitors – if you are not, just Google Vioxx or Celebrex!

Collectively, the triptans (exemplified by sumatriptan) are not a squeaky clean class of molecules either and bring with them potential cardiovascular liabilities that make them contraindicated in roughly 20% of migraineurs who are also diagnosed with high blood pressure, angina and several other cardiovascular-related events.  This is due to the non-specific vasoconstriction induced by triptans – which is great in the middle cerebral and meningeal arteries where migraines are suspected to occur but notsomuch in other arteries within the cardiovascular, pulmonary and renal systems.

Therefore, despite the marked advances in our understanding of the complex biology of migraines (i.e., the vasoconstriction and neuropeptide (CGRP) hypotheses) and the discovery of a variety of prescription medicines used to manage the clinical symptoms (the triptans), there remain considerable unmet needs requiring a focused eye towards improving both the efficacy and safety profile of future migraine treatments.

Although commercially-available triptans only work in about 40% of migraine patients, they continue to be the market leader used to combat migraine.  My opinion is that not all migraines are created equal and if you have found a treatment strategy (e.g., a triptan) that works well for you and one that you can tolerate – then by all means, keep doing what you are doing!

However, there is clear evidence that exists to support the discovery and development of therapies designed to work by a novel mechanism to treat migraine.  We (and other companies focused on this problem) are excited about the possibility to bring to the world a novel medication that demonstrates superior safety and possibly efficacy for the millions of patients suffering from acute migraine.  To find out more about our treatment approach for migraine and our company, please visit arielpharma.com to learn more.

For additional information on the prevalence of migraine, current treatment options or to read patient testimonials, the following websites are an excellent starting point:

www.migraineresearchfoundation.org

www.headaches.org

 

Read the first two parts of this series:

The Anatomy Of A Migraine Attack (Part One)

What Happens During A Migraine Attack (Part Two)

 

 

Weekly Neuroscience Update

People aren’t very good at media multitasking, but do it anyway because it makes them feel good, a new study suggests. The findings provide clues as to why multitasking is so popular, even though many studies show it is not productive.

A team of Montreal scientists has identified a blueprint for how memories are encoded. The findings may lead to a better understanding of memory impairments, as well as therapies for such neurodegenerative disorders as Alzheimer’s.

The way we use our hands may determine how emotions are organized in our brains, according to a recent study published inPLoS ONE. 

Researchers at Harvard, Yale, and the Massachusetts Institute of Technology have found the first evidence that meditation can alter the physical structure of our brains. Brain scans they conducted reveal that experienced meditators boasted increased thickness in parts of the brain that deal with attention and processing sensory input.

New test for early Alzheimer’s disease

John Mulcahy, Project Co-Ordinator, MSSI, Denis Stoiakine, CEO,NT-MDT Ireland and Dr Syed Tofail, Lead Scientist, MSS

In Ireland, over 44,000 people are affected by Alzheimer’s and other forms of dementia. There are 7.7 million new cases of dementia each year worldwide, implying that there is a new case of dementia somewhere in the world every four seconds. At present there is no test to screen for this disease. The World Alzheimer Report 2011 identified that the current lack of detection is a significant barrier to improving lives of people with Alzheimer’s disease and other dementias, their families and carers.

The research team based at the Materials and Surface Science Institute (MSSI), UL are leading a European consortium that is developing the nanoscope. Dr Syed Tofail, Lead Scientist on the project said; “Early detection of Alzheimer’s is critical in developing  effective treatments for the disease and there is currently no test available. Our technique would be able to detect Alzheimer’s-related amyloid plaques in the early stage with much more detail.”

The prototype developed will be easy to use, flexible and allow direct imaging of the chemistry and the structure of very small features. The technique uses infra-red radiation as a source of detection but breaks away from its physical diffraction limit so as to see features as small as 70 nanometers in lateral dimension, which is comparable to the size of a virus. The technique is also capable of seeing buried features without the need for destroying the surface of a cell or a material.

Read more on this story on the UL website.

What happens during a migraine attack?

The figure above shows our understanding of what happens during a migraine attack.  It is now thought that a migraine is triggered when a wave of electricity which starts in the trigeminal nerve on the side of the face stimulates the release of peptides such as CGRP and other substances that cause inflammation and makes other nerves more sensitive to pain. The wave of electricity then enters the brain and ripples across the surface of the brain – and together with CGRP causes blood vessels to dilate, as shown in Inset A above. In this way sensitization of the nerves often progresses from peripheral nerve cells on the skin to central neurons in the brain.

(Adapted from the American Society for Neuroscience).

Related Post:

The Anatomy of a Migraine Attack

Weekly Neuroscience Update

Advertisers and public health officials may be able to access hidden wisdom in the brain to more effectively sell their products and promote health and safety, UCLA neuroscientists report in the first study to use brain data to predict how large populations will respond to advertisements.

A team led by psychology professor Ian Spence at the University of Toronto reveals that playing an action videogame, even for a relatively short time, causes differences in brain activity and improvements in visual attention.

A miniature atom-based magnetic sensor developed by the National Institute of Standards and Technology (NIST) has passed an important research milestone by successfully measuring human brain activity. Experiments reported this week inBiomedical Optics Express verify the sensor’s potential for biomedical applications such as studying mental processes and advancing the understanding of neurological diseases.

A key protein, which may be activated to protect nerve cells from damage during heart failure or epileptic seizure, has been found to regulate the transfer of information between nerve cells in the brain. The discovery, made by neuroscientists at the University of Bristol and published in Nature Neuroscience and PNAS, could lead to novel new therapies for stroke and epilepsy.

Practices like physical exercise, certain forms of psychological counseling and meditation can all change brains for the better, and these changes can be measured with the tools of modern neuroscience, according to a review article now online at Nature Neuroscience.

A computer game designed to lift teenagers out of depression is as effective as one-on-one counselling, New Zealand doctors reported on Thursday in the British Medical Journal (BMJ).

How to give your brain a break

Over a 24-hour period we can process up to 70,000 thoughts, even as we sleep. Each day contains 86,400 seconds, so that equates to a different thought every 1.2 seconds, or two thoughts for every heartbeat. Basically, your brain never shuts up!

Over a 24-hour period we can process up to 70,000 thoughts, even as we sleep. Each day contains 86,400 seconds, so that equates to a different thought every 1.2 seconds – your brain never stops!

Left unchecked, this incessant chatter can turn to the dark side and become an chorus of self-criticism and blame. Negative thinking can become much more dominant than the positive and supportive kind.

Left unchecked, this incessant chatter can turn to the dark side and become an chorus of self-criticism and blame. Negative thinking can become much more dominant than the positive and supportive kind.

These thoughts tend to become stuck and repetitive ¿ leading to anxiety, depression and burn-out. Only by freeing ourselves from them can we grow calmer, more focused, more present and happier.

These thoughts tend to become stuck and repetitive — leading to anxiety, depression and burn-out.  Only by freeing ourselves from them can we grow calmer,  more focused, more present  and happier.

There is a simple solution: meditation. It has been proven to ease stress, improve metabolism, reduce pain, lower blood pressure and enhance brain function.
Meditation has been proven to ease stress, improve metabolism, reduce pain, lower blood pressure and enhance brain function. And all you need to do is . .. nothing.

(Extracted from Quiet The Mind, an illustrated guide on how to meditate by Matthew Johnstone)

Related Posts:

Set your brain to meditate

Your brain and the art of confusion

Weekly Neuroscience Update

An elderly man who has spent over ten years in a nursing home, barely able to answer yes or no questions—come alive when listening to music from his past is a reminder of the powerful, inspiring, and affecting power of music.

Talking to yourself has long been frowned upon as a sign of craziness, but a recent study published in the Quarterly Journal of Experimental Psychology suggests talking to yourself might actually help you find lost or hidden objects more quickly than being silent.

The longstanding mystery of how selective hearing works — how people can tune in to a single speaker while tuning out their crowded, noisy environs — is solved this week in the journal Nature by two scientists from the University of California, San Francisco (UCSF).

Evidence is now mounting that when we attend to objects in the periphery, critical information about them is transmitted, or ‘fed back’, to an unexpected part of the brain: a region that neuroscientists have traditionally believed represents only the ‘fovea’, our central visual field.

A recent study looked at brain scans while adults were being taught new words. Greater activity was shown with average readers when the words were taught in isolation, not in a full sentence.

An international team of scientists reported the largest brain study of its kind had found a gene linked to intelligence, a small piece in the puzzle as to why some people are smarter than others.

TEDMED: Matters of the Mind

Here’s another very interesting TEDMED Scribe from last week’s TEDMED meeting. Artists and neuroscientists illuminate the mind in Session 5, giving us access to the musical symphonies that heal, the symphonic sounds our brains make, and the thoughts and yearnings of the minds of the nonverbal.