Making sense of maps

Map designer Aris Venetikidis is fascinated by the maps we draw in our minds as we move around a city — less like street maps, more like schematics or wiring diagrams, abstract images of relationships between places. How can we learn from these mental maps to make better real ones? As a test case, he remakes the notorious Dublin bus map.

(Filmed at TEDxDublin)

Weekly Neuroscience Update

An aspirin a day may slow brain decline in elderly women at high risk of cardiovascular disease, research finds.

The hippocampus represents an important brain structure for learning. Scientists at the Max Planck Institute of Psychiatry in Munich discovered how it filters electrical neuronal signals through an input and output control, thus regulating learning and memory processes.

Scientists performing experimental brain surgery on a man aged 50 have stumbled across a mechanism that could unlock how memory works. The accidental breakthrough came during an experiment originally intended to suppress the obese man’s appetite, using the increasingly successful technique of deep-brain stimulation. Electrodes were pushed into the man’s brain and stimulated with an electric current. Instead of losing appetite, the patient instead had an intense experience of déjà vu. He recalled, in intricate detail, a scene from 30 years earlier. More tests showed his ability to learn was dramatically improved when the current was switched on and his brain stimulated.

Brain metastases are common secondary complications of other types of cancer, particularly lung, breast and skin cancer. The body’s own immune response in the brain is rendered powerless in the fight against these metastases by inflammatory reactions. Researchers in Vienna have now, for the first time, precisely characterised the brain’s immune response to infiltrating metastases. This could pave the way to the development of new, less aggressive treatment options.

Inside the teenage brain

Why do teenagers seem so much more impulsive, so much less self-aware than grown-ups? In this video, cognitive neuroscientist, Sarah-Jayne Blakemore, compares the prefrontal cortex in adolescents to that of adults, to show us how typically “teenage” behavior is caused by the growing and developing brain.

Weekly Neuroscience Update

Newly formed emotional memories can be erased from the human brain. This is shown by researchers from Uppsala University in a new study now being published by the academic journal Science. The findings may represent a breakthrough in research on memory and fear.

A growing body of research shows that children who suffer severe neglect and social isolation have cognitive and social impairments as adults. A study from Boston Children’s Hospital shows, for the first time, how these functional impairments arise: Social isolation during early life prevents the cells that make up the brain’s white matter from maturing and producing the right amount of myelin, the fatty “insulation” on nerve fibers that helps them transmit long-distance messages within the brain.

People with psychopathic tendencies have an impaired sense of smell, which points to inefficient processing in the front part of the brain [orbitofrontal cortex]. These findings by Mehmet Mahmut and Richard Stevenson, from Macquarie University in Australia, are published online in Springer’s journal Chemosensory Perception.

According to new research of MRI scans of children’s appetite and pleasure centers in their brains, the logos of such fast-food giants as McDonald’s, Pizza Hut, and Burger King causes those areas to “light up”.

New signs of future Alzheimer’s disease have been identified by researchers at Lund University and Skane University in Sweden. Dr. Peder Buchhave and his team explain that disease-modifying treatments are more beneficial if started early, so it is essential identify Alzheimer’s disease patients as quickly as possible.

A new study from MIT neuroscientists sheds light on a neural circuit that makes us likelier to remember what we’re seeing when our brains are in a more attentive state.

What we’re learning from 5,000 brains

Read Montague is interested in the human dopamine system — or, as he puts it in this illuminating talk from TEDGlobal 2012, that which makes us “chase sex, food and salt” and therefore survive.

Specifically, Montague and his team at the Roanoke Brain Study are interested in how dopamine and valuation systems work when two human beings interact with each other.

“We have a behavioral superpower in our brain and it at least in part involves dopamine,” says Montague in this talk. “We can deny any instinct we have for survival for an idea. No other species can do that.”

So how do we assign value to ideas, process the gestures of those around us, make complicated decisions, and create informed judgments about each other? Montague’s lab hopes to discover much more about how these processes work by “eavesdropping” on the brains of 5,000 to 6,000 participants all over the world as they play negotiation games. It’s fascinating research that could tell us more about our social nature. Because as Montague says, “You often don’t know who you are until you see yourself in interaction with people who are close to you, people who are enemies to you, and people who are agnostic to you.”

Source: TED blog

What stress does to your brain

A brain drawing with the prefrontal cortex highlighted.

By watching individual neurons at work, a group of psychologists at the University of Wisconsin-Madison has revealed just how stress can addle the mind, as well as how neurons in the brain’s prefrontal cortex help “remember” information in the first place.

Read this story in full here

Weekly Neuroscience Update

Have you ever wondered why some people find it so much easier to stop smoking than others? New research shows that vulnerability to smoking addiction is shaped by our genes. A study from the Montreal Neurological Institute and Hospital — The Neuro, McGill University shows that people with genetically fast nicotine metabolism have a significantly greater brain response to smoking cues than those with slow nicotine metabolism.

When children learn to play a musical instrument, they strengthen a range of auditory skills. Recent studies suggest that these benefits extend all through life, at least for those who continue to be engaged with music. But a study published last month is the first to show that music lessons in childhood may lead to changes in the brain that persist years after the lessons stop.

A team of Australian researchers, led by University of Melbourne has developed a genetic test that is able to predict the risk of developing autism spectrum disorder (ASD).

Recent findings by an international collaboration including IRCM researchers hold new implications for the pathogenesis of myotonic dystrophy.

Researchers at Newcastle University have revealed the mechanism by which neurons, the nerve cells in the brain and other parts of the body, age. The research opens up new avenues of understanding for conditions where the ageing of neurons are known to be responsible, such as dementia and Parkinson’s disease.
Finally, this week…a new study has shown that it’s possible to predict how well people will remember information by monitoring their brain activity while they study.

Inside The Language Brain

Why is it that humans can speak but chimpanzees, our closest living relatives, cannot?

The human brain is uniquely wired to produce language. Untangling this wiring is a major frontier of brain research. Peer into the mental machinery behind language with this feature video, which visits a brain-scanning laboratory—Columbia University’s Program for Imaging and Cognitive Sciences.

Columbia neuroscientist Joy Hirsch and New York University psychologist Gary Marcus explain what researchers have learned about how our brain tackles language—and what’s left to learn.

This is your brain on Jane Austen

Researchers observe the brain patterns of literary PhD candidates while they’re reading a Jane Austen novel. The fMRI images suggest that literary reading provides “a truly valuable exercise of people’s brains.”

Pictured above – test subject Matt Langione, a doctoral candidate at UC-Berkeley, reading Jane Austen’s ‘Mansfield Park’ in the mock scanning room. The researchers found that blood flow in the brain increases during such leisurely reading, but in different areas of the brain than when the subjects read the novel more closely.

Read full story here

Migraine Action Week

As part of Migraine Action Week, the Migraine Association of Ireland is holding a free information seminar entitled Approaches to Migraine Management on Saturday, September 15th from 10.30am-4pm in the Ballsbridge Hotel, Dublin.

Consultant neurologist Martin Ruttledge will give an overview of migraine. There will also be information on yoga, stress management, Buteyko breathing techniques. For more details, see migraine.ie or tel: 1850 200 378 and 01-8941280.

Read my three-part series on migraine:

The Anatomy of a Migraine Attack

What Happens During A Migraine Attack?

Easing The Pain Of Migraine Attacks