Weekly Neuroscience Update

*Diagram outlining the model procedures for one domain and one region. This process was repeated for all 33 domains and 82 regions. Credit: Network Neuroscience (2025).*

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

Researchers have discovered that problems with the brain’s waste-clearing system—the glymphatic system—may significantly raise the risk of developing dementia. In one of the most extensive studies to date, MRI data from 40,000 adults revealed that impaired cerebrospinal fluid (CSF) flow predicts dementia risk years before symptoms appear.

Statins might help protect the brain function of breast and lymphoma cancer patients for up to 2 years after their cancer treatment, according to a report in JAMA Network Open.

A study published in the journal Music and Medicine demonstrates that intraoperative music therapy significantly reduces the amount of propofol and fentanyl required during laparoscopic cholecystectomy performed under general anaesthesia. Patients exposed to therapeutic music also experienced smoother awakenings and lower physiological stress, as measured by decreased perioperative cortisol levels.

Scientists have used next-generation imaging technology to discover that when the brain is falling asleep, it shows a coordinated shift in activity.

A research team has conducted one of the most comprehensive studies on dopamine and decision-making in humans so far, providing evidence for effects of the former on the latter. Dopamine is a neurotransmitter involved in several functions, including motivation and reward.

Newly decoded brain circuits make memories more stable as part of learning, according to a new study.

Brain scans from American football players reveal subtle differences in the brain’s outer grooves when compared to scans from otherwise healthy men who never played contact or collision sports, a new study shows. Its authors say the findings could potentially predict which people are more at risk of chronic traumatic encephalopathy.

Researchers have uncovered an unexpected molecular partnership that reshapes understanding of how brain inflammation arises in Alzheimer’s disease.

Even when blood pressure is well controlled, older adults whose blood pressure fluctuates widely from one heartbeat to the next may be at greater risk for brain shrinkage and nerve cell injury, according to a recent study.

Finally, this week, new research suggests that a child’s gut microbiome at age 2 may influence their emotional health years later.

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Credit: *Neuroscience* (2025). DOI: 10.1016/j.neuroscience.2025.06.032

Memory loss may not simply be a symptom of getting older. New research shows that it’s tied to specific molecular changes in the brain and that adjusting those processes can improve memory.

An international consortium of researchers has created the largest-ever database compiling records of brain activity during sleep and dream reports. One of the first analyses of the database confirmed that dreams do not occur only during REM sleep, but also during deeper and calmer NREM stages. In these cases, brain activity resembles wakefulness more than deep sleep, as if the brain were “partially awake.”

A smartphone app for muscle relaxation significantly reduced migraine-related disability in patients visiting the emergency department.

A new study reveals that sleep-like slow-wave brain activity can persist for years in surgically disconnected brain hemispheres of awake epilepsy patients. Using EEG recordings, researchers found that the isolated cortex exhibits patterns similar to deep sleep, anesthesia, or vegetative states—suggesting absent or reduced awareness.

People 60 and older who are excessively sleepy during the day may have more problems with memory and thinking after surgery, suggests a study presented at the ANESTHESIOLOGY 2025 annual meeting.

Doctors and researchers at the University of Pittsburgh and UPMC have developed a new treatment for epilepsy patients who don’t respond to medication and aren’t candidates for surgery. Their approach, published in Nature Communications, uses deep brain stimulation (DBS) that is tailored to each patient’s unique brain wiring.

A new computational tool has uncovered genetic evidence directly linking Alzheimer’s disease to the loss of memory-making neurons, helping to resolve a decades-long mystery in dementia research.

While studies have linked brain areas to remembering personal experiences, brain areas involved in learning more impersonal information about the world remain unclear. In a new JNeurosci paper, researchers used fMRI on 29 human volunteers as they performed a learning task to shed light on how the brain acquires semantic, impersonal information.

Researchers have traced the earliest stages of multiple sclerosis (MS), showing that the immune system begins attacking the brain up to seven years before diagnosis.

New research has provided the strongest evidence yet that auditory verbal hallucinations—or hearing voices—in schizophrenia may stem from a disruption in the brain’s ability to recognise its own inner voice.

Adults with gum disease may be more likely to have signs of damage to the brain’s white matter than people without gum disease, according to a study published in Neurology Open Access.

A team of researchers has developed and tested a new virtual reality (VR) training task designed to help stroke survivors living with visuospatial neglect (VSN), a disabling condition that affects attention and awareness of one side of space. The exploratory case study is among the first to integrate audiovisual cues within a physiotherapy-based VR task to support rehabilitation.

Finally, this week, listening to music when you are over 70 years of age has been linked to a 39% reduction in the risk of dementia, according to a new study of over 10,800 older people.

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Participants were more likely to perceive the avatar’s expression as angry when they actively avoided the avatar, compared to when the avatar moved away from them. Credit: (C)Toyohashi University Of Technology.

A research team from the Cognitive Neurotechnology Unit and the Visual Perception and Cognition Laboratory at Toyohashi University of Technology has found that approach–avoidance behavior in a virtual reality (VR) environment modulates how individuals recognize facial expressions.

A McGill University-led clinical trial is the first in humans to show online brain training exercises can improve brain networks affecting learning and memory.

A new study reveals that the human brain synchronizes more accurately with rhythm when listening to music than when feeling it through touch. When people tap along to sound, slow rhythmic brain waves align with the perceived beat, helping maintain steady timing.

Psilocybin could be the future of mental health care, with promising findings emerging from Australia’s first research trial using psychedelics to treat depression.

An international research team led by a University of Ottawa Faculty of Medicine investigator has revealed intricate details about how nerve signals activate at the neuromuscular junction. This specialized synapse connects motor neurons to skeletal muscle fibers.

A ‘digital twin’ of your brain could predict mental health issues and slow cognitive decline.

A study published in Environment International concludes that air pollution during pregnancy is associated with slower brain maturation in newborns. It is the first study to analyze brain development within the first month of life.

A new clinical trial is investigating how advanced brain monitoring could improve the diagnosis and management of epilepsy.

University of California San Diego of Medicine researchers, in collaboration with the genetic testing company 23andMe, have identified regions of the human genome associated with cannabis use, uncovering new relationships with psychiatric, cognitive and physical health.

The conditions where you live may influence your brain health and risk for dementia, according to a new study.

Women are affected by severe depression twice as often as men. The reasons for this have not yet been fully clarified. One potential factor is sex-specific differences in the blood-brain barrier. Scientists are conducting research on the project “Leaky blood-brain barrier in major depressive disorder.” A particular focus is on sex-specific differences.

New research reveals how uniquely wired human brains can perceive the world in strikingly similar ways.

A new study published in Scientific Reports indicates that amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have an extremely high geographic association, even after controlling for race, gender, wealth, latitude, and access to neurological health care.

Finally, this week, a ‘ flight simulator‘ for the brain reveals how we learn—and why minds sometimes go off course.

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Opioid blockade (Naltrexone condition; right side) relative to placebo (Control condition; left side) selectively eliminated attentional broadening after reward receipt (A), but did not change attentional narrowing after reward anticipation (B) or reward-related performance speed on the lexical decision task (C). Credit: Psychological Medicine (2025).

Feeling good doesn’t just lift our mood—it also helps us stay flexible and resilient. A study by an international team of neuroscientists shows that natural brain opioids released after rewards play a key role in broadening attention, offering fresh insights into stress, cognition, and well-being.

A ground-breaking study has shown that ALS may actually be an autoimmune disease.

Engaging in creative experiences, such as music, dance, visual arts, and even specific video games, can slow brain aging and promote healthier brain function, according to a new international study by the Global Brain Health Institute (GBHI), published in Nature Communications.

Can your brain attune itself to a foreign language before you’re born? A team of neuropsychology researchers has found that it can.

A new study reveals that the brain’s social perception pathway—a network that processes faces, gaze, and speech—is already active at birth or shortly thereafter. Using advanced imaging data, researchers showed that newborns exhibit robust connectivity in regions responsible for visual and social processing.

Scientists have discovered why mental maps tend to fade with age.

A new study has identified five distinct “sleep-biopsychosocial” profiles that connect how we sleep with our brain networks, mental health, cognition, and lifestyle. Using data from over 700 participants, researchers found that different sleep patterns—ranging from poor quality to resilience and short duration—each showed unique neural connectivity patterns.

A large-scale international study has revealed that autism diagnosed in early childhood is genetically and developmentally distinct from autism diagnosed later in life.

Scientists have developed a new mathematical model of memory that explores how information is encoded and stored. Their analysis suggests that memory works best in a seven-dimensional conceptual space — equivalent to having seven senses. The finding implies that both humans and AI might benefit from broader sensory inputs to optimize learning and recall.

Researchers have identified a rare type of brain cell that may drive the chronic inflammation and neurodegeneration seen in progressive multiple sclerosis (MS).

A new study shows that bullying activates distress pathways in the brain within seconds. Tweens and adults who viewed first-person bullying videos displayed heightened activity in social and emotional brain networks, alongside strong autonomic threat responses.

New research sheds light on the mechanisms by which humans can isolate and focus on individual sounds in noisy environments.

Scientists have revealed that intentional memory control—deciding what to remember or forget—is more potent than emotional influence when forming long-term memories. Participants were more likely to recall words they were told to remember than those carrying emotional weight, even though emotion sometimes strengthened recall or caused false memories.

Finally, this week, a new study reveals how the brain organizes and directs its slowest activity.

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Conceptual framework for brain–body states. Credit: *Trends in Neurosciences* (2025).

There is growing evidence that the heart has a strong influence on thinking and feeling.

Your chronological age may say 65, but your brain could be acting a decade younger — or older — depending on your life experiences. That’s the message from a study by University of Florida researchers, who found that optimism, good sleep, social support, and other positive factors were strongly linked with healthier brains. The findings suggest that how people live and cope with stress can measurably influence the pace of brain aging, even in those living with chronic pain.

An international research team has made a significant breakthrough in predicting neurodegenerative diseases.

In a discovery that could reshape our understanding of memory, neuroscientists have found that forgetting is not just a glitch in the brain but is actually a finely tuned process, and dopamine plays a crucial role.

A new study shows that lifelong social advantages can slow biological aging.

Recent research explores the ways brain cells communicate, revealing fresh insight into the progression of Alzheimer’s disease. A multidisciplinary team used advanced imaging and computational modeling to analyze the “crosstalk” between neurons and their supporting glial cells in the human brain. This approach highlights the brain’s interconnected cellular network.

A growing number of U.S. adults—particularly those under 40—are reporting serious challenges with memory, concentration and decision-making, according to a new study published in Neurology.

Researchers at the University of Michigan are using artificial intelligence to predict the health consequences that sport-related concussions might have on student athletes over the course of their college athletic careers.

A recent study shows that sugary drinks don’t just affect physical health—they may also raise the risk of depression in women by disrupting the gut microbiome.

New research has shown that walking enhances how the brain processes auditory information, sharpening responses compared to standing still. When participants walked in a figure-eight path, their brains responded more strongly to sounds, and turning direction influenced whether responses were enhanced or suppressed in each ear.

Extreme instances of stress can cause lasting changes to the brain itself. This could leave some people more vulnerable to addiction, a University of Mississippi study concludes.

People who sleep poorly are more likely than others to have brains that appear older than they actually are. This is according to a comprehensive brain imaging study from Karolinska Institutet, published in the journal eBioMedicine.

An advanced AI tool can detect tiny brain lesions that cause severe epilepsy in children, allowing faster diagnosis, more precise treatment and a potential cure.

New research has found that people with narcolepsy type 1 exhibit patterns of slow brain pulsations that resemble those seen in healthy sleep. The findings, published in PNAS, suggest that orexin—a neuropeptide involved in maintaining wakefulness—may play a key role in the brain’s fluid-clearing system, known as the glymphatic system.

Finally this week, scientists have developed a brain-inspired semiconductor that can adjust its responses based on experience, much like human neurons do through “intrinsic plasticity.”

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A research collaboration has identified the specific nerve pathways responsible for relaying pain signals from the bowel to the brain, paving the way for new irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) treatments.

Game-based training improves not only the cognitive abilities of people with initial signs of developing dementia, but also leads to positive changes in the brain, according to two new studies.

A next-generation neuroprosthetic hand that restores a sense of touch is moving into a pivotal home-use clinical trial. The “iSens” system uses implanted electrodes to read muscle intent and stimulate nerves, relaying fingertip sensations to the brain so the prosthesis feels embodied.

A new breakthrough demonstrates how robots can now integrate both sight and touch to handle objects with greater accuracy, much like humans.

Researchers have traced a neural mechanism that explains why humans explore more aggressively when avoiding losses than when pursuing gains. Their work reveals how neuronal firing and noise in the amygdala shape exploratory decision-making.

Scientists have found a way to stop brain cancer cells spreading by essentially ‘freezing’ a key molecule in the brain.

Researchers have developed an ultrasound device that can precisely stimulate areas deep in the brain without surgery, opening up new possibilities for neurological research and the treatment of disorders such as Parkinson’s disease.

Artificial intelligence can detect and interpret social features between people from images and videos almost as reliably as humans, according to a new study published in the journal Imaging Neuroscience.

A large study of nearly 13,000 adults found that consuming high levels of certain artificial sweeteners is associated with faster declines in memory and cognitive function over an eight-year period. The effect was particularly strong in people with diabetes and those under 60. While the study does not prove causation, it raises concerns about the long-term brain health risks associated with common sugar substitutes.

Experiments have shown that AI can develop in-context learning abilities after extensive incremental practice, much like humans do.

A new study suggests that autism may be linked to the rapid evolution of brain cell types unique to humans. Researchers have found that outer-layer neurons in the human brain evolved significantly faster than in other apes, with notable changes in autism-associated genes.

A new study shows that brain iron levels, measured using a specialized MRI technique, can predict cognitive decline years before symptoms of Alzheimer’s disease appear.

People with chronic insomnia may experience faster declines in memory and thinking skills as they age—along with brain changes that can be seen on imaging scans—than people who do not have chronic insomnia, according to a study published in Neurology.

Researchers have discovered how the brain develops reliable visual processing once the eyes open.

Scientists discovered how the brain uses objects to anchor our sense of direction, solving part of the mystery of spatial navigation. Experiments in mice showed that cells in the postsubiculum fired strongly when facing an object, while cells in other directions were suppressed, sharpening orientation.

In adults aged 60 years and older, tinnitus, especially severe and prolonged tinnitus, is significantly associated with cognitive impairment, according to a study published in Brain Sciences.

A more precise and personalized form of electric brain stimulation may be a more effective and faster treatment for people with moderate to major depression compared to other similar treatments, according to a UCLA Health study.

Finally this week, researchers may have found a way to limit the debilitating damage strokes can cause.

Weekly Neuroscience Update

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A new study published in Scientific Reports has introduced a promising diagnostic tool that could dramatically shorten the long wait times many families face when seeking evaluations for autism and attention-related conditions. The research team used artificial intelligence to analyse subtle patterns in how people move their hands during simple tasks, identifying with surprising accuracy whether someone is likely to have autism, attention-deficit traits, or both. The method, which relies on wearable motion sensors and deep learning, could one day serve as a rapid and objective screening tool to help clinicians triage children for further assessment.

New research is investigating how childhood adversity rewires brain circuits that control emotion, memory, and attention, increasing the risk of impulsive and pathological aggression.

A groundbreaking study has revealed that genes linked to mental and neurodegenerative disorders, such as autism, depression, and Parkinson’s, begin influencing brain development during the earliest fetal stages. These genes are already active in neural stem cells—the progenitors that form the brain—long before symptoms arise.

Researchers at the University of Michigan have illuminated a complete sensory pathway showing how the skin communicates the temperature of its surroundings to the brain.

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may be closer to personalized care, according to new research that shows how the disease disrupts interactions between the microbiome, immune system, and metabolism.

A new study using direct recordings from human brains reveals how the amygdala and hippocampus coordinate to form and retrieve emotional memories.

A personalised brain stimulation system powered by AI that can safely enhance concentration from home has been developed by researchers from the University of Surrey, the University of Oxford and Cognitive Neurotechnology. Designed to adapt to individual characteristics, the system could help people improve focus during study, work, or other mentally demanding tasks.

In the largest study of its kind, researchers linked irregular sleep patterns to elevated risk for 172 diseases.

Neuroscientists have grown a novel whole-brain organoid, complete with neural tissues and rudimentary blood vessels. This advance could usher in a new era of research into neuropsychiatric disorders such as autism.

Researchers have successfully mapped the entire neural circuit responsible for transmitting cool temperature signals from the skin to the brain.

A new brain imaging study reveals that how people expect pain relief—through visual cues or treatment explanations—can significantly influence how much pain they actually feel. External cues, like symbols signaling less pain, consistently reduced pain perception and altered brain regions tied to pain processing.

Finally this week, a new international study confirmed a significant post-pandemic rise in disorders of gut-brain interaction, including irritable bowel syndrome (IBS) and functional dyspepsia.

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*Experimental design, ripple detection, and ripple properties. Credit: Nature Communications (2025)*

A research team has identified, for the first time in humans a key neurophysiological mechanism in memory formation: ripple-type brain waves—high-frequency electrical oscillations that mark and organize the different episodes or fragments of information that the brain stores as memories.

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory.

New research shows that signs of Alzheimer’s disease can already be detected in the blood of people as young as their 40s. Finnish scientists found elevated Alzheimer’s-related biomarkers in middle-aged adults, especially among those with maternal history or kidney disease.

A new study questions whether playing youth football leads to harmful protein buildup in the brain.

Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment, finds a large medical records study.

A large genetic study reveals that cannabis use disorder is strongly linked to increased risk for multiple psychiatric disorders, including depression, PTSD, ADHD, and schizophrenia.

A common sugar substitute, erythritol, widely used in “sugar-free” and low-carb products, may increase stroke risk by damaging brain blood vessel cells. A new study found that erythritol exposure reduced nitric oxide, increased vessel constrictors, impaired clot-busting abilities, and boosted free radical production in these cells.

Finally, this week, neuroscientists have discovered a signature ‘wave’ of activity as the brain awakens from sleep.

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Coloured regions show where brain volume was associated with deviant lifestyle and antisocial behavior in individuals with psychopathic traits. Credit: European Archives of Psychiatry and Clinical Neuroscience (2025).

A recent study has shed light on the brain structure differences associated with psychopathy—a condition known to be one of the strongest predictors of persistent violent behaviour. The findings are published in the journal European Archives of Psychiatry and Clinical Neuroscience.

Researchers are using a new approach to brain imaging that could improve how drugs are prescribed to treat Parkinson’s disease.

An analysis of over 375 trials shows that structured exercise significantly reduces depression and anxiety in children and teens. Low-intensity resistance activities like light weights were most effective for easing anxiety, while moderate mixed-mode programmes worked best for depression, especially when lasting under 12 weeks.

A new technology that uses clinical MRI machines to image metabolic activity in the brain could give researchers and clinicians unique insight into brain function and disease.

Diets rich in phosphate additives, commonly found in processed foods, can increase blood pressure by triggering a brain signaling pathway and overactivating the sympathetic nervous system that regulates cardiovascular function, UT Southwestern researchers discovered. Their findings could lead to treatment strategies for patients with hypertension caused by overconsumption of foods containing high levels of phosphates.

The long-standing belief that left-handed people are more creative has been challenged by a new meta-analysis of over a century of research.

New research proposes a unified theory of brain function based on criticality—a state where the brain teeters between order and chaos, allowing it to learn, adapt, and process information optimally. When the brain strays from this delicate balance, cognitive performance weakens, and neurological disorders such as Alzheimer’s may begin to take hold.

A drug used for Parkinson’s disease has been shown to be effective in reducing the symptoms of difficult to treat depression, according to a study led by the University of Oxford.

A recent study shows that older adults may compensate for age-related cognitive decline by enhancing activity in a specific brain region linked to attention—the locus coeruleus (LC). In a brain imaging study, older participants showed stronger LC responses when interpreting ambiguous facial expressions, compared to younger adults.

Individuals with versus those without tinnitus have significantly lower scores on cognitive function tests, according to a recent study published in Frontiers in Neurology.

New research shows how the brain navigates emotional transitions, using music as a tool to map changing neural patterns. Scientists found that emotional responses in the brain depend heavily on the listener’s prior emotional state.

A clinical trial has revealed that Ambroxol, a common cough medicine in Europe, may help slow cognitive decline in people with Parkinson’s disease dementia.

In a study of 200 former professional rugby players (aged 30–61 years old), researchers from Imperial College London, University College London and the UK Dementia Research Institute found no cases of early-onset dementia.

Finally this week, new research findings show how synaptic connections in the cerebral cortex can strengthen during sleep, offering insight into how the brain continues learning even while we rest.

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The analysis pipeline of the study, with select figures created using BioRender. Credit: *Nature Communications* (2025)

Scientists have developed a novel, detailed map at the subcellular level of a brain region frequently impacted by Alzheimer’s disease. This groundbreaking achievement represents a significant advancement in understanding the mechanisms underlying the development of this neurodegenerative condition.

New research shows that AI can identify complex regional pain syndrome (CRPS) with over 90% accuracy by analyzing gut microbiome patterns.

Mindfulness exercises paired with music were found to engage both neural and cardiac systems, potentially reducing symptoms of anxiety and depression. A recent study showed that live and virtual music mindfulness sessions lowered stress and altered states of consciousness, though only live sessions fostered social connection.

A long-term study shows that teenagers who maintain or increase physical activity levels are less likely to develop symptoms of depression.

Researchers have developed a brain-computer interface (BCI) that enables computer cursor control and clicking, using neural signals from the speech motor cortex. One participant with amyotrophic lateral sclerosis (ALS) used the interface for daily life activities, including independent control of a personal desktop computer and text entry.

New research shows that targeting emotional processing is key to treating and managing chronic pain.

In a first-of-its-kind clinical study, researchers have shown that patients with treatment-resistant PTSD were symptom-free up to six months after completing traditional therapy paired with vagus nerve stimulation (VNS).

Scientists using living human brain tissue have shown for the first time how a toxic form of a protein linked to Alzheimer’s can stick to and damage the connections between brain cells.

People whose biological age is higher than their chronological age may be more likely to develop dementia than people whose biological age matches or is lower than their chronological age, according to a study published online in Neurology. Biological age is based on biomarkers of aging such as lung function, blood pressure and cholesterol.

A recent study reveals that oxygen tension elevation during weeks four to six promotes neurogenesis in brain organoids, regulated by neuroglobin. The research is published in Science Advances.

Obstructive sleep apnea, a condition that causes lower oxygen levels during sleep, is linked to degeneration of brain regions associated with memory through damage to the brain’s small blood vessels, according to a study published in Neurology.

A new theory suggests that psychedelics promote empathy, insight, and psychological flexibility by making the brain’s right hemisphere temporarily dominant over the left.

A revolutionary microscopy method called LICONN enables scientists to reconstruct brain tissue and map synaptic connections using standard light microscopes. By embedding brain tissue in hydrogel, expanding it, and imaging at nanoscale resolution, researchers achieve a detailed view of neuronal architecture previously only possible with electron microscopy.

A new music therapy-based tool called MuSICCA may transform how healthcare teams assess consciousness in children with severe brain injuries.

Research from Emory University has identified a biological connection between inflammation and deficits in motivation in individuals with schizophrenia, offering new hope for treating symptoms that have long been resistant to existing therapies.

A Yale-led study shows that the senses stimulate a region of the brain that controls consciousness—a finding that might inform treatment for disorders related to attention, arousal, and more.

Finally this week, a new study has debunked the common myth that autistic people are less effective communicators than non-autistic individuals. Researchers found no difference in how well information was shared between autistic-only, non-autistic-only, or mixed groups.