Weekly Neuroscience Update

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When selecting a video game to play, opting to turn on your Wii may provide a different experience than playing your Xbox, according to a study from Mississippi State University.

Excessive alcohol use accounts for 4% of the global burden of disease, and binge drinking particularly is becoming an increasing health issue. A new review article published Cortex highlights the significant changes in brain function and structure that can be caused by alcohol misuse in young people.

Working with patients with electrodes implanted in their brains, researchers have shown for the first time that areas of the brain work together at the same time to recall memories. The unique approach promises new insights into how we remember details of time and place.

Researchers at the University of Glasgow are hoping to help victims of stroke to overcome physical disabilities by helping their brains to ‘rewire’ themselves.

Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown.

Neuroscientists have released the results of a new study that examines how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.

Neuroscience researchers from Tufts University have found that our star-shaped brain cells, called astrocytes, may be responsible for the rapid improvement in mood in depressed patients after acute sleep deprivation. This in vivo study, published in the current issue ofTranslational Psychiatry, identified how astrocytes regulate a neurotransmitter involved in sleep. The researchers report that the findings may help lead to the development of effective and fast-acting drugs to treat depression, particularly in psychiatric emergencies.

UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus – which provides short-term storage for memories – to the prefrontal cortex’s longer term “hard drive.”

Researchers have found altered connectivity in the brain network for body perception in people with anorexia: The weaker the connection, the greater the misjudgement of body shape.

A group of scientists planning to map all the major connections in the human brain began studying their first test subjects in August. The $30 million Human Connectome Project will trace the main neural pathways that link the roughly 500 major regions in the brain, illuminating how biological circuitry underlies our mental functions. MRI scans of 1,200 people, including 300 pairs of twins, will be used to compile an atlas of communication routes throughout the brain. The resulting blueprint will also reveal how brain connectivity varies from person to person.

Exercise doesn’t just make you fitter – it makes you smarter too!

Exercise is important in keeping your heart and lungs healthy. We know for decades that the effort required in exercise allows life-giving oxygen to travel quicker and in greater amounts to all the tissues of the body – allowing the cells in them to grow and divide. A noticeable exception to this rule is the brain.

Neurons are different

Nerve cells or neurons are notoriously bad at dividing. Rather than divide, a neuron survives by making up to 10,000 connections to neighbouring neurons – and this is the key to how we learn and recall as memories are created and strengthened.  This compromise works well for the first four decades of life however by your 50’s a gradual loss of neurons and their connections starts to take it toll resulting in a noticeable reduction in cognition as we find it harder to remember, especially recent events. 

An unexpected finding

Recent scientific findings from Columbia University show that exercise is important in helping to reverse this age-related loss of neurons. In this study in a small group of middle-aged people, exercising just an hour a day, four times a week, for three months triggers the growth of new neurons – a feat which has previously proved almost impossible for neuroscientists to achieve using drugs. Neuroscientists are still working out the possible reasons why simple exercise is so powerful at triggering the birth of neurons but a clue may be that the brain is very well supplied by blood vessels needed to deliver the food and oxygen to help make and maintain the trillions of synapses in the brain. In fact the brain is one of the most oxygen-sensitive organs of the body. It receives 20% of the cardiac output and accounts for about 25% of overall resting oxygen consumption. In addition, the brain as a highly vascular organ is very sensitive to changes in blood perfusion. It seems the extra increase in blood perfusion and life-giving oxygen associated with exercise may invigorate the brain to such a degree that it starts to actually grow new neurons again.

Exercise is as important as drugs

The finding that exercise triggers the brain to grow new nerve cells is a truly stunning discovery that will have implications for public healthcare policies for an increasingly ageing population. In addition, new treatments for brain illness such as Alzheimer’s disease and head injury may involve a combination of different therapies such as medication, psychological therapies, social support, self-help techniques and now, most importantly exercise. This combined approach will treat the person as a whole, and marks the beginning of the journey back to wellness and a normal life.

So the message is simple –if you want to stay smart just get out there and exercise.