Weekly Neuroscience Update

New research has revealed how acute stress can affect the connectivity of different brain regions, leading to increased neural activity and changes in behavior.

New research has found that sleep has a crucial role in preparing the body to fight off infections. During sleep, the immune system produces cytokines, which help in fighting infections, inflammation, and stress. In contrast, sleep deprivation can weaken the immune system and increase the likelihood of getting sick. The study also found that sleeping for longer periods before an infection occurs can improve the chances of fighting it off.

A research team has found that people with chronic pain in multiple parts of the body had a higher risk of dementia and experienced broader and faster cognitive decline, including memory, executive function, learning, and attention.

Researchers have discovered how changes in blood vessels in the eye can be used to predict the progression of age-related macular degeneration (AMD), a leading cause of blindness. The researchers used high-resolution imaging techniques to measure the density of blood vessels in the retina of patients with AMD. They found that decreased blood vessel density in certain areas of the retina was associated with the progression of the disease.

A new study has identified changes in the levels of certain proteins in the blood of women with perinatal depression (depression during pregnancy or after childbirth).

A new brain connection discovered by researchers can explain how early-life stress and adversity trigger disrupted operation of the brain’s reward circuit, offering a new therapeutic target for treating mental illness. Impaired function of this circuit is thought to underlie several major disorders, such as depression, substance abuse and excessive risk-taking.

A study at the University of Tsukuba in Japan has found that routine exercise helps prevent cognitive impairment in older adults, with exercising alone being beneficial, but exercising with others having an even greater positive effect.

Although investigators have made strides in detecting signs of Alzheimer’s disease using high-quality brain imaging tests collected as part of research studies, a research team has developed an accurate method for detection that relies on routinely collected clinical brain images. The advance could lead to more accurate diagnoses.

Finally, this week, seizures can be predicted more than 30 minutes before onset in patients with temporal lobe epilepsy, opening the door to a therapy using electrodes that could be activated to prevent seizures from happening, according to new research.

Weekly Neuroscience Update

Exercise can improve your cognitive and mental health — but not all forms and intensities of exercise affect the brain equally. The effects of exercise are much more nuanced, as specific intensities of exercise over a long period of time are associated with different aspects of memory and mental health, according to a new study.

A research team has shown for the first time that non-invasive stimulation of the vagus nerve at the ear can strengthen the communication between stomach and brain within minutes.

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer’s disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new study.

A new report highlights the advances and challenges in prevention, clinical care, and research in traumatic brain injury, a leading cause of injury-related death and disability worldwide.

Neurons in an area of the brain responsible for memory (known as the entorhinal cortex) are significantly larger in SuperAgers compared to cognitively average peers, individuals with early-stage Alzheimer’s disease, and even individuals 20 to 30 years younger than SuperAgers — who are aged 80 years and older, reports a new study.

Children who were infected with COVID-19 show a substantially higher risk of developing type 1 diabetes (T1D), according to new research.

Researchers have discovered a biological mechanism that increases the strength with which fear memories are stored in the brain. The study provides new knowledge on the mechanisms behind anxiety-related disorders, and identifies shared mechanisms behind anxiety and alcohol dependence.

Finally this week, a new study demonstrates how an AI algorithm can estimate biological age with high accuracy based on brain scan images.

Weekly Neuroscience Update

When perceiving rhythm, the brain makes two separate decisions based on grouping and prominence. The groupings mutually inform each other to generate an overall rhythmic perception.

Face pareidolia, a phenomenon where the brain is tricked into seeing human faces in inanimate objects, may occur as a result of the brain processing the perceived facial expression in the same sequential way it perceives a human face. Neuroscientists at the University of Sydney now say how our brains identify and analyse real human faces is conducted by the same cognitive processes that identify illusory faces.

Researchers have identified a novel population of neurons in the temporal pole that links facial perception to long-term memory.

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet published in The Lancet Psychiatry.

A new study reveals very young infants can perceive objects that older infants, children, and adults can not see due to a phenomenon called visual backward masking.

Infant boys with a gut bacterial composition high in Bacteroidetes were found in a new study to have more advanced cognitive and language skills one year later compared to boys with lower levels of the bacteria. The finding was specific to male children.

Brain cells snap DNA in more places and in more cell types than previously realized in order to express genes for learning and memory.

Researchers have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson’s disease model.

New research shows daydreaming and mind-wandering appear to occur when parts of the brain fall asleep while other areas remain awake.

Finally this week, a diet rich in fermented foods enhances the diversity of gut microbes and decreases molecular signs of inflammation, according to researchers at the Stanford School of Medicine.

Weekly Neuroscience Update

Children who are physically active have higher cognitive function and increased functional connectivity in the brain later in life than those who are less active, a new study reports.

Canadian researchers have built and validated an online calculator that empowers individuals 55 and over to better understand the health of their brain and how they can reduce their risk of being diagnosed with dementia in the next five years. Their process was published today in the Journal of Epidemiology and Community Health, and the calculator is available at projectbiglife.ca.

Researchers studying prions–misfolded proteins that cause lethal incurable diseases–have identified for the first time surface features of human prions responsible for their replication in the brain.

Middle-aged people with depressive symptoms who carry a genetic variation called apolipoprotein (APOE) ε4 may be more at risk to develop tau protein accumulations in the brain’s emotion- and memory-controlling regions, a new study suggests.

Frequent strenuous exercise increases the risk of developing motor neuron disease (MND)/ALS in certain people, new research has found.

Combining brain scans with AI technology, researchers were able to accurately predict the likelihood of a person developing schizophrenia in those with a family history of the psychiatric disorder.

A new study reveals very young infants can perceive objects that older infants, children, and adults can not see due to a phenomenon called visual backward masking.

Subtle changes in fractal motor activity regulation in cognitively healthy women may be a sign of preclinical Alzheimer’s disease, researchers report.

Deep brain stimulation appears to be safe, effective, and provides symptom improvements for at least one year in patients with treatment-resistant schizophrenia.

New research details the interplay between proteins involved in controlling the body’s stress response and points to potential therapeutic targets when this response goes awry.

A new research paper published in the American Journal of Clinical Nutrition last week showed that a low Omega-3 Index is just as powerful in predicting early death as smoking.

Finally this week, a new study sheds light on how migraines may occur and why those who are susceptible to migraines see improvements in symptoms as they age.

Weekly Neuroscience Update

Around 4000 nerve fibres connect to this single neuron
Google/Lichtman Laboratory

Google has helped create the most detailed map yet of the connections within the human brain. It reveals a staggering amount of detail, including patterns of connections between neurons, as well as what may be a new kind of neuron.

Researchers have identified three biomarkers in blood samples that confirm the link between exercise and improved cognitive function in older adults.

A new study reveals what goes on in the brain when a person embarks on a musical collaboration project.

Chronic inflammation in the gut may propel processes in the body that give rise to Parkinson’s disease, according to new research.

The largest study of its kind has unveiled new insights into how genes are regulated in dementia, including discovering 84 new genes linked to the disease.

A new study shows that a deep neural network model can accurately predict the brain age of healthy patients based on electroencephalogram data recorded during an overnight sleep study, and EEG-predicted brain age indices display unique characteristics within populations with different diseases.

Finally this week, scientists have identified an area of the brain that drives cravings for protein-rich food.

Weekly Neuroscience Update

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The image is adapted from the University of Toronto news release.

An experiment led by University of Toronto psychologists has shown for the first time that grapheme-colour synesthesia  –   a condition in which individuals sense colours associated with letters and numbers – provides a clear advantage in statistical learning – an ability to discern patterns – which is a critical aspect of learning a language. The result provides insight into how we learn, and how children and adults may learn differently.

Scientists might have found an early detection method for some forms of dementia.

Neuroimaging helps researchers observe what happens in the brain as a person is rotated. The study, which gives insight into how the brain moves after the head stops moving, also provides critical information for advancing studies of TBI.

Esketamine combined with antidepressants acts rapidly to help alleviate symptoms in those with treatment-resistant depression.

Inflammation appears to reduce reward response in females. Reduced activity in the brain’s reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men.

A new study has found that a new nerve stimulation therapy to increase blood flow could help patients with the most common type of stroke up to 24 hours after onset.

The results of a new study suggest that virtual reality could make life easier for people with dementia. The authors conclude that virtual reality helped the participants recall memories and contributed to an improvement in patients’ relationships with caregivers.

Researchers have identified average levels of biological and anatomical brain changes with Alzheimer’s disease over 30 years before symptoms appear.

Magnetic stimulation of the brain improves working memory, offering a new potential avenue of therapy for individuals living with Alzheimer’s disease and other forms of dementia, according to new research.

Sleep in teenagers can be improved by just one week of limiting their evening exposure to light-emitting screens on phones, tablets and computers,

Finally this week, using Magnetic Resonance Imaging (MRI), scientists have captured 3D images that show how infants’ brains and skulls change shape as they move through the birth canal just before delivery.

 

 

Weekly Neuroscience Update

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Music and mindful music listening may help people who have suffered strokes recover their impaired cognitive abilities more effectively, new research suggests.

The loss of memory and cognitive function known to afflict survivors of septic shock is the result of a sugar that is released into the bloodstream and enters the brain during the life-threatening condition. This finding, published in the Proceedings of the National Academy of Sciences, explains the premature mental aging that follows septic shock and may shed light on memory loss in other diseases.

Researchers have identified a new autoimmune disease that causes muscle pain and weakness.

Scientists used brain signals recorded from epilepsy patients to program a computer to mimic natural speech–an advancement that could one day have a profound effect on the ability of certain patients to communicate.

Scientists have created a “neural decoder” that translates brain activity into speech.

Autism diagnosis becomes stable starting at 14 months of age, researchers report. The accurate diagnosis of ASD, four months earlier than previously believed, leads to more opportunities for early interventions.

A new two-tier diagnostic blood test which evaluates both amyloid beta and tau, can help detect Alzheimer’s disease in presymptomatic patients.

Researchers are officially defining a new brain disorder that mimics Alzheimer’s disease. The disorder will be known as LATE, which stands for limbic-predominant age-related TDP-43 encephalopathy.

Finally this week, a new deep learning algorithm can reliably determine what visual stimuli neurons in the visual cortex respond best to.

 

Weekly Neuroscience Update

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Image: Pixabay

How quickly do we experience the benefits of exercise? A new study of healthy older adults shows that just one session of exercise increased activation in the brain circuits associated with memory – including the hippocampus – which shrinks with age and is the brain region attacked first in Alzheimer’s disease.

Using a unique computational framework they developed, a team of scientist cyber-sleuths has identified 104 high-risk genes for schizophrenia.

Reduced connectivity between the amygdala and ventrolateral prefrontal cortex has been identified in children on the autism spectrum who exhibit disruptive behaviors, compared to those on the spectrum who do not. Findings suggest this distinct brain network could be independent of core autism symptoms.

A specially designed computer program can help diagnose post-traumatic stress disorder (PTSD) in veterans by analyzing their voices.

Using CRISPR-Cas9 gene editing, researchers identified actionable pathways responsible for the growth of glioblastoma stem cells. By reverse engineering brain cancer cells, multiple potential new targets for cancer treatments have been uncovered.

Obesity is associated with alterations in brain structure, including lower grey matter volume and smaller globus pallidus volume according to new research. 

Researchers have found certain clues in the brain waves that show the reason why angry dreams occur when a person sleeps. The results of the study titled, “EEG Frontal Alpha Asymmetry and Dream Affect: Alpha Oscillations Over the Right Frontal Cortex During REM Sleep and Pre-Sleep Wakefulness Predict Anger in REM Sleep Dreams,” were published in the Journal of Neuroscience.

People with the specific genotype of the Cannabinoid receptor 1 gene may be more prone to cannabis use disorder.

A rapid memory system transition from the hippocampus to the posterior parietal cortex is stabilized as we sleep. Sleep and repeated rehearsal of memory jointly contribute to long-term memory consolidation.

A new study confirms that a simple blood test can reveal whether there is accelerating nerve cell damage in the brain. 

Finally, this week, using a combination of movie clips and neuroimaging, researchers find people have positive biases to those they feel are more like them, even if they are unable to see the person’s face.

Weekly Neuroscience Update

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As we age, slow brain waves during non-REM sleep fail to time contact with sleep spindles efficiently, leading to a lessened ability to form new memories correctly, a new study reports.

Researchers report children are more attentive and have improved memory when they exercise at their own pace, rather than embark on exhaustive exercise.

Inflammation in the blood plays a key role in “chemo-brain,” according to a published pilot study that provides evidence for what scientists have long believed.

A new study sheds light on the neurons tasks glial cells perform to insure brain activity is optimized.

According to researchers, children who eat fish at least once a week score four points higher on IQ tests and sleep better than those who consume fish less frequently, or not at all.

A new study looks how it may be possible to help reduce trauma associated with bad memories while we sleep.

Researchers reveal even after one short, ten minute, burst of exercise, cognitive processing and attention improve temporarily.

Finally this week, a new study supports the hypothesis that people with focal epilepsy are more susceptible to mood disorders, such as depression and anxiety.

Weekly Neuroscience Update

 

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A new guideline for medical practitioners says they should recommend twice-weekly exercise to people with mild cognitive impairment to improve memory and thinking.

Researchers reveal Parkinson’s patients have more copies of mitochondrial DNA in the brain stem, leading to increased cell death within that area.

Musical training may enhance the ability to process speech in noisy settings, a new study shows.

A new study reveals the piriform cortex is able to archive long term memory, but requires instruction from the orbiotfrontal cortex to indicate the event is to be stored as a long-term memory.

Greater muscle strength is associated with better cognitive function in ageing men and women, according to a new Finnish study

Researchers have discovered a new biomarker that can help diagnose Huntington’s disease. They note the findings could result in the development of treatments to postpone neuron death in those who carry the Huntington’s gene mutation, but who do not currently show symptoms of the disease.

A new study reveals the superior temporal gyrus appears to be critical for voice recognition.

Researchers have identified several new genes responsible for Alzheimer’s disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

Finally this week, a new study adds to evidence that current clinical tools can fail to capture autism presentations in females.