Weekly Neuroscience Update

Microscopic photos observed through changes of the flourescence of the synapse sensor (SynapShot) by cultivating the neurons of an experimental rat and expressing the SynapShot. The changes in the synapse that is created when the pre- and post-synaptic terminals come into contact and the synapse that disappears after a certain period of time are measured by the fluorescence of the SynapShot. Credit: KAIST Optogenetics & RNA therapeutics Lab

New research has observed the processes of memory and cognition in real-time.

A new study reveals significant findings in the fight against Long Covid. Through a comprehensive analysis of blood serum from 113 patients, researchers discovered changes in blood serum proteins related to the complement system, coagulation, and tissue injury in Long Covid patients.

New research has found that exercising both before and after learning optimizes memory formation, with a notable 10% improvement in remembering motor skills.

A new study employs generative AI to shed light on how the human brain processes memories for learning, imagination, and planning. The study used a computational model resembling the hippocampus and neocortex’s neural networks to simulate memory encoding and retrieval.

A new study has reported that SARS-CoV-2, the virus that causes COVID, can infect dopamine neurons in the brain and trigger senescence—when a cell loses the ability to grow and divide.

Researchers have taken the first steps to treat Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein aggregation associated with those diseases.

A neuroscientific study is paving the way for improving the diagnosis and treatment of Alzheimer’s.

A new study reveals limitations in the current use of mathematical models for personalized medicine, particularly in schizophrenia treatment. Although these models can predict patient outcomes in specific clinical trials, they fail when applied to different trials, challenging the reliability of AI-driven algorithms in diverse settings.

Research into the nature of memory reveals how cells that store information are stabilized over time.

A new study explores how infants and toddlers acquire language. Findings reveal early comprehension begins around 6-7 months, and significant improvements in language understanding occur around a child’s first birthday.

New research looks at ways to predict when a migraine attack will occur.

Researchers at the National Institutes of Health have found overactivation in many brain regions, including the frontal and parietal lobes and the amygdala, in unmedicated children with anxiety disorders. They also showed that treatment with cognitive behavioral therapy (CBT) led to improvements in clinical symptoms and brain functioning.

An international research has proposed a new model for classifying Parkinson’s disease.

A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, scientists report.

3D bioprinting sheds light on why blood vessel curvature may foster brain cancer metastasis.

Researchers achieved a significant advancement in robotics by replicating human-like variable speed walking using a musculoskeletal model. This model, steered by a reflex control method akin to the human nervous system, enhances our understanding of human locomotion and sets new standards for robotic technology.

There is a difference between how the brains of healthy older adults perceive color compared to younger adults, finds a new study.

Researchers conducted a study to explore the neuroscientific basis of fairness in social situations, investigating the interplay between personal interests and societal norms. By applying electric brain stimulation to 60 participants, the researchers pinpointed specific brain regions crucial to fairness decisions.

Finally this week, scientists have made a significant discovery using an artificial neural network model, suggesting that musical instinct may emerge naturally from the human brain.

Weekly Neuroscience Update

Credit: eLife (2023)

Researchers have investigated the shared and unique neural processes that underlie different types of long-term memory: general semantic, personal semantic, and episodic memory, suggesting that these memory types all use the same network of the brain, rather than relying on different areas of the brain altogether. This questions a previous theory that characterizes general semantic and episodic memory as two distinct systems. Instead, the authors suggest that different long-term memory types could be viewed as a spectrum, where they rely on activating the same areas of the brain at differing magnitudes.

Scientists can now pinpoint where someone’s eyes are looking just by listening to their ears.

Using a specialized device that translates images into sound, neuroscientists have shown that people who are blind recognize basic faces using the part of the brain known as the fusiform face area, a region that is crucial for the processing of faces in sighted people.

People with long COVID exhibit patterns of changes in the brain that are different from fully recovered COVID-19 patients, according to new research.

What is the mechanism that allows our brains to incorporate new information about the world, and form memories? New work led by Dr. Tomás Ryan from Trinity College Dublin shows that learning occurs through the continuous formation of new connectivity patterns between specific engram cells in different regions of the brain.

New research indicates that acoustic stimulation of the brain may ease persistent symptoms in individuals who have experienced mild traumatic brain injury in the past.

Scientists have discovered that Alzheimer’s-related changes in brain networks extend beyond memory and attention, impacting sensory and motor circuits. These findings challenge previous assumptions about Alzheimer’s effects.

A pivotal discovery in addiction science has found a correlation between microstructural deficits in the prefrontal cortex-habenula tract and the development and maintenance of addiction.

Researchers have unveiled a pioneering technique for charting the intricate conversations occurring within our brains. Such insights are key to decoding behavioral alterations in neurological disease patients. The innovative tool, CaMPARI, allows scientists to witness brain activity in real-time, marking active neurons red and inactive ones green. This breakthrough could offer pathways to better treatments and understanding of diseases like Alzheimer’s.

A team of neuroscientists has found evidence suggesting that the neural development of babies still in the womb is impacted by the language they hear spoken by their mothers as they carry them.

A new study has discovered a link between a new gene pathway and structural brain anomalies in some people who stutter into adulthood, opening up promising research avenues to enhance the understanding of persistent developmental stuttering.

Finally this week, researchers have developed a tool that simplifies the identification of errors in neural networks used for image recognition.

Weekly Neuroscience Update

Schematic of preprocessing and model training

Researchers have, for the first time ever, used AI to develop an algorithm they term “HistoAge” which predicts age at death based on the cellular composition of human brain tissue specimens with an average accuracy of within 5.45 years. This powerful tool can also identify neuroanatomical regions vulnerable to age-related changes, an indicator of potential cognitive diseases.

Scientists have uncovered why night shift work is associated with changes in appetite. The findings could help the millions of people who work through the night and struggle with weight gain.

The brain circuitry disrupted in Alzheimer’s disease appears to influence memory through a type of brain wave known as theta oscillation, a team of researchers report. The findings, published in Nature Communications, could help researchers design and evaluate new treatments for Alzheimer’s, a condition that affects millions of people around the globe and has no cure.

A new study suggests that a healthy heart may help prevent Alzheimer’s—and this gives hope for new treatments.

Researchers have shown the potential of a new gene therapy approach to silence human sensory neurons (nerve cells) as a means of treating persistent pain. Many current drugs for chronic pain are highly addictive, which makes it important to discover new alternatives.

Scientists have developed new tools, based on AI language models, that can characterize subtle signatures in the speech of patients diagnosed with schizophrenia.

Can plant-derived nutrients alter gut bacteria to affect brain function? A team of scientists investigated this question in a study of overweight adults. Their findings, published in the journal Gut, suggest that dietary fiber can exert influence on both the composition of gut bacteria and the reward signals in the brain and associated food decision-making.

New guidance has been issued for clinicians on the determination of brain death, also known as death by neurologic criteria

Researchers have shown it is possible to detect tell-tale signs of Parkinson’s disease 20–30 years before symptoms appear. Their work opens the door to screening programs and preventative treatments long before irreversible damage is done.

Finally this week, there is evidence that some form of conscious experience is present by birth, and perhaps even in late pregnancy, an international team of researchers has found.

Weekly Neuroscience Update

Credit: Nature (2023)

A new study has identified the link between memory and appetite.

Scientists have made a ‘paradigm shifting’ discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer’s disease and potentially Down syndrome.

Researchers have analyzed which physiological indicators recorded when watching a movie can predict the audience’s assessment. It turned out that the activity of zygomaticus major (the “smiling muscle”), heart rate variability and EEG indicators can tell us most about the viewer’s impression of the movie.

The largest genetic study of its kind has discovered specific changes in our DNA that increase the risk of developing epilepsy.

Researchers found that the skin, not pre-existing genetic programming, instructs nerve cells on how to mature for specific sensory tasks. The findings showcase that skin cues determine whether nerve endings develop to detect sensations in hairy or hairless skin. If corroborated by further research, this discovery could pave the way for therapies to mend damaged nerves or better comprehend congenital neuropathies.

A new study has explored the link between infant birthweight, gestational age and future cognitive problems.

Researchers have successfully developed temporary, organic electrodes that can be seamlessly integrated into biological systems. The method opens up a future where bioelectronics can be implanted in and removed from the body without surgery.

New research shows wildfire smoke impacts on the brain.

A new study has found that, among a sample of 152 young athletes exposed to repetitive head impacts (RHI) who were under age 30 at the time of death, 41.4% (63) had neuropathological evidence of CTE, a degenerative brain disease caused by RHI.

New research supports the idea that the brains of older adults who maintain physical fitness by engaging in regular strenuous exercise more closely resemble those of younger adults.

Researchers have succeeded in transforming brain signals into audible speech. By decoding signals from the brain through a combination of implants and AI, they were able to predict the words people wanted to say with an accuracy of 92 to 100%. Their findings are published in the Journal of Neural Engineering.

Finally this week, a virtual reality study has revealed a link between a sense of presence and cognitive abilities.

Weekly Neuroscience Update

Smaller Left vmPFC was associated with future smoking. Credit: Nature Communications (2023)

Levels of gray matter in two parts of the brain may be linked to a desire to start smoking during adolescence and the strengthening of nicotine addiction, a new study has shown.

Researchers have enabled machine learning to accurately predict Parkinson’s disease subtypes using stem cell images. This breakthrough showcases computer models classifying four Parkinson’s subtypes, with top accuracies reaching 95%. This could revolutionize personalized medicine and aid in more targeted drug research for Parkinson’s.

A large international team of medical researchers has found that the severity of COVID-19 infections in children over the course of the pandemic varied by age and viral variant.

Researchers have illuminated how our brain maintains focus amidst distractions. Their study identifies “visual-movement” neurons in the lateral prefrontal cortex (LPFC) that use coordinated activity called “beta bursts” to suppress distracting stimuli and ensure attention remains on rewarding tasks. This discovery gives a deeper understanding of cognitive focus and offers insights into disorders like ADD and OCD.

More cases of children born with abnormal brain development may have genetic explanations than previously thought, according to a recent study published in JAMA Neurology.

Hearing impairment may cause difficulties in social interactions, but new research indicates that social struggles experienced by deaf individuals are likely not due to brain alterations, but rather due to non-supportive environments.

Scientists have identified a series of processes that help the brain adapt to damage caused by breakdowns in circuits that govern movement, cognition and sensory perception.

For the first time, researchers have discovered that the ventral tegmental area (VTA) of the brain—a key structure involved in motivation and reward appreciation—has altered connectivity patterns with specific brain regions in patients with obesity. Individuals with obesity have hyper-connectivity of the VTA with part of the ventral occipitotemporal cortex (visual processing for food images) and hypo-connectivity with the left inferior frontal gyrus (associated with cognitive control), according to a new study in Obesity.

Researchers have identified a key pathway, involved in inflammation, which appears to be activated in people with long COVID who have symptoms of “brain fog.”

Using a novel approach of precision neuroimaging and high-resolution functional magnetic resonance imaging (fMRI), a team of neuroscientists and physicists have discovered previously unknown cortical networks and shed light on the anatomical organization of the human memory system.

A pioneering scientific study has shown that the effects of multiple concussions in rugby players continue to have an impact on their brain even in retirement. 

Researchers have coupled the measurements of brain waves associated with disorders of consciousness (DoC) with glucose usage in specific brain areas, identifying where in the brain the waves might be generated.

A new study shows that brains with Alzheimer’s disease have subnormal levels of important dietary antioxidants.

A breakthrough project mapping brain changes in nearly 1,300 people diagnosed with six different types of mental illness has revealed the extraordinary diversity of brain changes found in people with conditions like major depression and schizophrenia.

Researchers have unveiled a promising link between adult education and reduced dementia risk. 

Neuroscientists have shown that adversities permanently change the functioning of the brain. Furthermore, an aberrant reaction of the brain to adversities is related to anxiety symptoms. This may have predictive value for the development of psychiatric disorders.

Finally this week, a new study identifies sex differences in the brain cell types responding to stress.

Weekly Neuroscience Update

Factors associated with healthy aging in Latin American populations. Credit: Nature Medicine (2023)

Researchers at Trinity College Dublin studying the factors influencing healthy brain aging in Latin American and Caribbean (LAC) countries find the lessons learned there, can also be applied to home.

Immune cells in the brains of people who had Alzheimer’s disease appear to behave differently than those who had healthy brains for their age, according to an analysis of the cells’ gene activity. The finding suggests it might be possible to treat Alzheimer’s disease by altering the behavior of these cells.

The longer a person has type 2 diabetes, the more likely they may be to experience changes in brain structure, a new study finds.

Using human “mini-brain” models known as organoids, scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions. The specific cells are known as excitatory cortical neurons.

Psilocybin, the active ingredient in psychedelic mushrooms, shows promise for the transitional treatment of episodic migraines in early clinical trials, according to a recent review.

Researchers have discovered that a neural marker of error detection in the brain’s visual system previously considered pre-attentive may actually require attention and that subtle visual irregularities may be revealed by other neural markers.

A new study has demonstrated that self-organization of neurons as they learn follows a mathematical theory called the free energy principle.

The neural network related to speech is mostly located in the left cerebral hemisphere, while singing has been primarily associated with the structures of both hemispheres. However, a new study indicates that the left hemisphere has a greater significance, including in terms of singing, than previously thought.

A new digital headset designed to measure alterations in brain function could change decisions about how quickly an athlete is ready to return to play after a concussion.

A new study suggests stimulating the sense of smell can boost memory. Older adults exposed to odors while they slept performed better on verbal memory tests and showed improved function in a brain pathway that supports memory formation, according to the study, published in the journal Frontiers in Neuroscience.

Finally this week, researchers have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells.

Weekly Neuroscience Update

Credit: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023). DOI: 10.1016/j.bpsc.2023.07.003

Researchers have recently been exploring the potential of psychedelic drugs, such as psilocybin and lysergic acid diethylamide (LSD) for treating depression and other mental disorders. Recent research compared the brains of those who had taken psychedelics to those who meditated or were hypnotized. The researchers found that while some may report similar experiences or feelings under these different states of consciousness, what is happening in their brains is very different. Despite the similarities in brain activity between psilocybin and LSD, the changes they induced were markedly different. It suggests that psychedelics, meditation, and hypnosis operate differently and possess distinct underlying mechanisms.

A new study has used multi-omics profiling to track the markers of aging in women.

In a recent review published in the journal Trends in Cognitive Science on August 3rd, a group of social scientists describe how the functions of social media algorithms are misaligned with human social instincts meant to foster cooperation, which can lead to large-scale polarization and misinformation.

Researchers have proposed a strategy to stratify risk of progression from mild cognitive impairment to Alzheimer’s disease.

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin superfamily of hormones, including insulin, insulin-like growth factor 1 (IGF1), and insulin-like growth factor 2 (IGF2), play a crucial role not only in regulating blood sugar, metabolism, and growth, but also in healthy brain development and function, including learning and memory.

Finally this week, how people feel about their sleep has a greater impact on their well-being than what sleep-tracking technology says about their sleep quality, new research has found.

Weekly Neuroscience Update

A new study sheds light on gender differences in risk-taking behavior. The research reveals women are more averse to risk than men due to heightened sensitivity to potential losses. Conversely, men, exhibiting greater optimism, are more willing to engage in risk-taking.

Researchers have identified specific brain network connections associated with anosognosia, a condition where patients are unaware of their neurological or psychiatric deficits.

Scientists have discovered children’s ability to process emotional cues is largely established by the time they start school. Analyzing brain scans from children aged five to 15, the study revealed that such brain activity becomes increasingly similar to their peers as they reach adolescence. The research emphasizes the importance of early intervention to address issues related to understanding emotional cues.

Recent neuroscience studies underscore the profound impact of sleep and sleep disorders on memory.

In a paper published in Science Advances, an international team reveal the discovery of sequence variants in the gene ABCC9 that influence the pitch of voices. The scientists found that ABCC9 variants associate with higher voice pitch in both men and women. The same sequence variants are also linked to higher pulse pressure, a cardiovascular risk factor, highlighting links between voice pitch and health-related traits.

Researchers have discovered a promising new avenue for treating glioblastoma, a deadly brain cancer.

Research led by the University of Texas Health Science Center, San Antonio, Texas, has looked into premature brain aging in individuals with type 1 diabetes. The findings of this study show an increase in brain aging among individuals with type 1 diabetes without any early signs of AD-related neurodegeneration. These increases were associated with reduced cognitive performance, but according to the authors, the abnormal patterns observed in the samples were modest.

Finally this week, intricate links between breathing and memory recall have been unraveled by recent scientific research, painting a more complex picture of our cognitive processes.

Weekly Neuroscience Update

A new study shows that walking can enhance connections within and between three critical brain networks, one of which is linked to Alzheimer’s disease. The research, involving older adults with normal cognitive function and those with mild cognitive impairment, showcased an improvement in memory recollection abilities after a 12-week walking exercise regimen. The brain activity observed was stronger and more synchronized post-exercise, providing hope for combating cognitive impairment and potentially delaying the onset of Alzheimer’s dementia.

Most antidepressants used for chronic pain are being prescribed with “insufficient” evidence of their effectiveness, scientists have warned.

Researchers have found a correlation between patients with rheumatoid arthritis and Parkinson’s disease. In their paper published in JAMA Neurology, researchers found a significantly higher risk of Parkinson’s disease (PD) in patients with rheumatoid arthritis (RA).

Researchers have delved into the brain’s grey and white matter, investigating the impacts of fibromyalgia. Using MRI, the team detected reduced grey matter volume in the pain-processing areas of fibromyalgia patients.

Neuroscientists have discovered how vitamin D deficiency impacts the development of neurons, contributing to disorders such as schizophrenia. These findings underscore the importance of vitamin D in the structural differentiation of dopaminergic neurons and suggest that maternal vitamin D deficiency might alter how early dopaminergic circuits form.

Finally this week, researchers have cracked the mystery behind how the Botulinum neurotoxin type-A, also known as Botox, infiltrates neurons. 

Weekly Neuroscience Update

Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-38248-4

Scientists have found that the gut microbiome holds Parkinson’s disease markers and may indicate a method of early diagnosis.

Deep sleep, also known as non-REM slow-wave sleep, may help reduce memory loss in older adults facing a heightened burden of Alzheimer’s disease. The research indicates that superior amounts of deep sleep can act as a protective factor against memory decline in those with existing high amounts of Alzheimer’s disease pathology, potentially helping to alleviate some of dementia’s most devastating outcomes.

Researchers have discovered new genetic risk factors for non-Alzheimer’s dementia, specifically Lewy body dementia (LBD) and frontotemporal dementia (FTD).

Scientists have made strides in uncovering the mechanisms underlying memory formation and consolidation in the brain during rest or sleep. A new study focuses on the role of the hippocampus, a brain region important for memory, and its place cells which “replay” neuronal sequences. The researchers built an artificial intelligence model to better understand these processes, discovering that sequences of experiences are prioritized during replay based on familiarity and rewards. The AI agent was found to learn spatial information more effectively when replaying these prioritized sequences, offering valuable insight into the way our brains learn and process information.

New research finds that the brains of otherwise healthy military personnel who are exposed to explosions show an abnormal brain accumulation of amyloid-beta protein—a protein that plays a role in the development of Alzheimer’s disease.

A new study has found that people with a genetic risk for psychosis have an imbalance of glutamate and GABA neurotransmitters in their brains, specifically in the hippocampus. This imbalance is associated with hippocampal atrophy, which may lead to the development of psychotic symptoms.

Researchers have developed human brain organoids that contain microglia, the immune cells of the brain. These organoids allow researchers to study how microglia develop and function in a more realistic setting than previous models.

Researchers used artificial intelligence to analyze speech in Parkinson’s disease patients, revealing distinct patterns. The AI found Parkinson’s patients used more verbs but fewer nouns and fillers in their speech, even before cognitive decline typically associated with PD was evident.

A research team has found that the risk of long COVID and its symptoms present very differently across diverse populations.

A new study sheds light on the potential role of diet in preventing dementia. The analysis explored the relationship between gut health and Alzheimer’s disease, uncovering a strong link between specific types of gut bacteria and the likelihood of developing dementia. The findings highlight the significance of gut microbiota in brain health and provide insights into the underlying mechanisms of Alzheimer’s disease.

Finally this week, researchers have created a revolutionary device that emulates the human eye’s ability to see colour.