Tag Archives: neurons

Weekly Neuroscience Update

UCL Medical staff discussing an image of a human brain

Researchers at University College London have made a breakthrough in the way that drugs could be delivered to the brain, tackling the difficult problem of constructing drugs which are able to pass through the blood-brain barrier – a mechanism which prevents many chemicals in the bloodstream from passing into the brain, including synthetic compounds administered as medication as well as harmful environmental toxins.

For older adults looking to sharpen their mental abilities, it might be time to log on to Facebook. Preliminary research findings from the University of Arizona suggest that men and women older than 65 who learn to use Facebook could see a boost in cognitive function.

A single concussion may cause lasting structural damage to the brain, according to a new study published online in the journal Radiology.

In an effort to better evaluate and prevent concussions and head traumas, researchers at Johns Hopkins University have developed a computer model to identify what types of jarring movements to the body can cause injury to the brain

A team of sleep researchers has confirmed the mechanism that enables the brain to consolidate memory and found that a commonly prescribed sleep aid enhances the process. Those discoveries could lead to new sleep therapies that will improve memory for aging adults and those with dementia, Alzheimer’s and schizophrenia.

How do neurons store information about past events? In the Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw, a previously unknown mechanism of memory trace formation has been discovered. It appears that at least some events are remembered thanks to geometry.

It is possible to tell who a person is thinking about by analyzing images of his or her brain. Our mental models of people produce unique patterns of brain activation, which can be detected using advanced imaging techniques according to a study by Cornell University neuroscientist Nathan Spreng and his colleagues.

Columbia University Medical Center (CUMC) researchers have found the first evidence that selective activation of the dentate gyrus, a portion of the hippocampus, can reduce anxiety without affecting learning.


Weekly Neuroscience Update

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A research team at Northwestern University are studying the connection between memory and sleep, and the possibilities of boosting memory storage while you snooze.

For the first time, scientists have used a new combination of neural imaging methods to discover how the human brain adapts to injury. The research, published in Cerebral Cortex, shows that when one brain area loses functionality, a “back-up” team of secondary brain areas immediately activates, replacing not only the unavailable area but also its confederates.

New research suggests that testing a portion of a person’s saliva gland may be a way to diagnose Parkinson’s disease. The study was released today and will be presented at the American Academy of Neurology’s 65th Annual Meeting in San Diego, March 16 to 23, 2013.

In a promising finding for epileptic patients suffering from persistent seizures known as status epilepticus, researchers have reported that new medication could help halt these devastating seizures.

Tübingen neuroscientists have shown how decision-making processes are influenced by neurons.

EPFL scientists find evidence that psychological wounds inflicted when young leave lasting biological traces—and a predisposition toward violence later in life

The production of new neurons, known as neurogenesis, was found to be induced in the adult normal cortex by the antidepressant fluoxetine, as reported in a study published online last week in Neuropsychopharmacology. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the thesis that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for neurodegenerative diseases and psychiatric disorders.

photo credit: Toni Blay via photopin cc


How to build a brain

A team of researchers from the University of Waterloo have built what the claim is the world’s largest simulation of a functioning brain.

The purpose is to help scientists understand how the complex activity of the brain gives rise to the complex behavior exhibited by animals, including humans.

The model is called Spaun (Semantic Pointer Architecture Unified Network). It consists of 2.5 million simulated neurons. The model captures biological details of each neuron, including which neurotransmitters are used, how voltages are generated in the cell, and how they communicate.

Spaun uses this network of neurons to process visual images to control an arm that draws Spaun’s answers to perceptual, cognitive and motor tasks.

For more information, see: http://nengo.ca/build-a-brain/


Weekly Neuroscience Update

Mind wandering may increase creative thinking, according to a new international study.

Simple mental activity such as reading, writing, playing games and doing puzzles may protect brain health in old age, according to a new study.

Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to researchers at the Graduate School of Biomedical Sciences at Mount Sinai School of Medicine.

A small molecule known to regulate white blood cells has a surprising second role in protecting brain cells from the deleterious effects of stroke, Johns Hopkins researchers report.

Scientists have revealed the minutely detailed pain map of the hand that is contained within our brains, shedding light on how the brain makes us feel discomfort and potentially increasing our understanding of the processes involved in chronic pain.

People with Parkinson’s disease benefit from exercise programs on stationary bicycles, with the greatest effect for those who pedal faster, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).

A new method to study widespread networks of neurons responsible for our memory has been discovered by scientists from the Max Planck Institute for Biological Cybernetics.

The first study to estimate rates of traumatic brain injury (TBI), without relying on official figures, suggests the worldwide incidence of TBI could be six times higher than previously estimated.

MRI shows changes in the brains of people with post-concussion syndrome (PCS), according to a new study published online in the journal Radiology. Researchers hope the results point the way to improved detection and treatment for the disorder.

photo credit: pamlau.com via photopin cc


From neurons to networks

Both a young child’s brain and our young, global Internet brain are in highly creative, experimental, innovative states of rapid development — just waiting to make connections. So, here’s a question for the 21st century: How do we help shape both of these young, rapidly growing networks to set a course for a better future? These were the questions that led filmmaker, Tiffany Shlainme, to make this short film.

Read more


Weekly Neuroscience Update

Researchers have found that neurons in a specific region of the frontal cortex, called the anterior cingulate cortex, become active during decisions involving competitive effort.

In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.

Researchers have shown that activity in a certain region of the brain changes as children learn to reason about what other people might be thinking.

The human brain contains billions of neurons that are arranged in complex circuits, which enable people to function with regard to controlling movements, perceiving the world and making decisions. In order to understand how the brain works and what malfunctions occur in neurological disorders it is crucial to decipher these brain circuits. A new study, which is featured in the August 9 edition of Nature reveals that MIT neuroscientists have now come closer towards this goal, by discovering that two major classes of brain cells repress neural activity in specific mathematical ways by which one type subtracting from overall activation, whilst the other type divides it.

That fact that heavy drinking impacts the brain of developing youths is a well-known fact. However, now researchers from the University of California, San Diego School of Medicine and VA San Diego Healthcare System have discovered that certain patterns of brain activity could also help to predict which youths are at risk of becoming problem drinkers. The study is featured online in the August edition of the Journal of Studies on Alcohol and Drugs. The study involved functional magnetic resonance imaging (fMRI) of 12 to 16 year old teenagers’ brains before they started drinking and who had an fMRI three years later. About half of the teenagers started drinking heavily over the 3-year period but the researchers noted that the fMRI scans taken before these group of teenagers started drinking, they already showed less fMRI response in areas of the brain that were associated earlier with heavy drinking.

Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

Neuroscientists from The Scripps Institute have identified a specialized population of stem cells that have an impressive vocational calling: higher brain functioning. It’s an important finding that holds promise for the treatments of serious cognitive disorders — including those that impact on conscious function. And it also reveals how humans and other mammals are able to have such big brains.

Neuroscientists have discovered that the universal saying of “living in the moment” may be impossible. A study published in the journal Neuron reveals that neuroscientists have identified an area in the brain, which is responsible for using past decisions and outcomes to guide future behavior. The study is the first of its kind to analyze signals linked to metacognition, known as a person’s ability to monitor and control cognition, which researchers describe as “thinking about thinking.”


Know Your Neurons

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Different Types of Neurons A. Purkinje cell B. Granule cell C. Motor neuron D. Tripolar neuron E. Pyramidal Cell F. Chandelier cell G. Spindle neuron H. Stellate cell (Credit: Ferris Jabr; based on reconstructions and drawings by Cajal)

The Know Your Neurons series on the  Scientific American website features some great information on the discovery and naming of neurons, alongside some terrific historical images.

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Human hippocampus stained with Golgi’s method (Credit: Wikimedia Commons)

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Cajal’s drawing of Purkinje cells and granule cells in a pigeon’s brain (Credit: Wikimedia Commons)

Learn more: click here


Weekly Update: Brain Research

Using a sling or cast after injuring an arm may cause your brain to shift quickly to adjust, according to a study published in the January 17, 2012, print issue of Neurology®. The study found increases in the size of brain areas that were compensating for the injured side, and decreases in areas that were not being used due to the cast or sling.

A  new UC Davis study shows how the brain reconfigures its connections to minimize distractions and take best advantage of our knowledge of situations.

Neuroscientists at Kessler Foundation have documented increased cerebral activation in patients with multiple sclerosis (MS) following memory retraining using the modified Story Memory Technique (mSMT).  This is the first study to demonstrate that behavioral interventions can have a positive effect on brain function in people with cognitive disability caused by MS, an important step in validating the clinical utility of cognitive rehabilitation.

A program designed to boost cognition in older adults also increased their openness to new experiences, researchers report, demonstrating for the first time that a non-drug intervention in older adults can change a personality trait once thought to be fixed throughout the lifespan.

Researchers from the Institute of Psychiatry (IoP) at King’s College London have, for the first time, identified the facial expression of anxiety. The facial expression for the emotion of anxiety comprises an environmental scanning look that appears to aid risk assessment. The research was published this week in the Journal of Personality and Social Psychology.

New research from Uppsala University, Sweden, shows that a specific brain region that contributes to a person’s appetite sensation is more activated in response to food images after one night of sleep loss than after one night of normal sleep. Poor sleep habits can therefore affect people’s risk of becoming overweight in the long run. The findings are published in the Journal of Clinical Endocrinology & Metabolism.

Teenagers are more susceptible to developing disorders like addiction and depression, according to a paper published by Pitt researchers Jan. 16 in the Proceedings of the National Academy of Sciences.

Harvard scientists have developed the fullest picture yet of how neurons in the brain interact to reinforce behaviors ranging from learning to drug use, a finding that might open the door to possible breakthroughs in the treatment of addiction.

Virtual reality-enhanced exercise, or “exergames,” combining physical exercise with computer-simulated environments and interactive videogame features, can yield a greater cognitive benefit for older adults than traditional exercise alone, according to a new study published in the February issue of the American Journal of Preventive Medicine.

Sleeping after a traumatic event might lock in bad memories and emotions, a new study has found.

A team of researchers at the MedUni Vienna’s Department of Neurophysiology (Centre for Brain Research) has discovered a previously unknown effect of opioids - that opioids not only temporarily relieve pain, but at the right dose can also erase memory traces of pain in the spinal cord and therefore eliminate a key cause of chronic pain.

 


Weekly Round Up

Image Source: The Dana Foundation

Our senses of sight and hearing work closely together, perhaps more than people realize, a new UCLA psychology study shows.

A team of neurobiologists  has shown for the first time that cortex, the largest area of the brain that is typically associated with higher functions such as perception and cognition, is also a prominent site of emotional learning.

Tiny electric currents applied across regions of the brain can improve hand movements in recovering stroke patients for a short period, an Oxford University study has demonstrated.

For the first time, scientists have proven that cannabis harms the brain. But the same study challenges previously-held assumptions about use of the drug, showing that some brain irregularities predate drug use.

How might keeping patients awake during surgery lead to the more successful removal of brain tumours? James Keidel, in his shortlisted entry for the 2011 Wellcome Trust Science Writing Prize, explains.

Researchers from the University of Bristol have discovered that a chemical compound in the brain can weaken the synaptic connections between neurons in a region of the brain important for the formation of long-term memories. The findings, published in the Journal of Neuroscience, may also provide a potential explanation for the loss of memory associated with Alzheimer’s.


Weekly Round Up

Researchers have identified the group of neurons that mediates whether light arouses us or not.

Providing support to a loved one offers benefits to the giver, not just the recipient, a new brain-imaging study by UCLA life scientists reveals.

There’s growing evidence that the brains of autistic children are very different from the brains of other youngsters. Now a new study that found an excess of brain cells in children with autism comes closer to pinpointing the origins of the condition: in utero versus in toddlerhood.

Finally this week, scientists have found a direct link between the number of ‘Facebook friends’ a person has and the size of particular brain regions. Commenting on the study, Dr John Williams, Head of Neuroscience and Mental Health at the Wellcome Trust, said: “We cannot escape the ubiquity of the internet and its impact on our lives, yet we understand little of its impact on the brain, which we know is plastic and can change over time. This new study illustrates how well-designed investigations can help us begin to understand whether or not our brains are evolving as they adapt to the challenges posed by social media.”


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