Category Archives: Lifestyle

Weekly Neuroscience Update

medium_46044113Advice to “sleep on it” before making a big decision may be wise, according to new brain-imaging research.

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.An important aspect of chronic neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s or prion disease, is the generation of an innate within the brain. Results from the study open new avenues for the regulation of the inflammatory reaction and provide new insights into the understanding of the biology of , which play a leading role in the development and maintenance of this reaction.

A study conducted at the University of Granada and the University of York in Toronto, Canada, has revealed that bilingual children develop a better working memory –which holds, processes and updates information over short periods of time– than monolingual children.

Good mental health and clear thinking depend upon our ability to store and manipulate thoughts on a sort of “mental sketch pad.” In a new study, Yale School of Medicine researchers describe the molecular basis of this ability — the hallmark of human cognition — and describe how a breakdown of the system contributes to diseases such as schizophrenia and Alzheimer’s disease.

Your eyes aren’t just advanced visual systems capturing images of what’s around you. New research published in the Journal of Neuroscience shows that when our eyes perceive visual stimuli, it gets encoded in our brains in ways that change our emotional reactions.

In a pair of new papers, researchers at the University of California, San Diego School of Medicine and the Royal Netherlands Academy of Arts and Sciences upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons, and describe how a compound linked to Alzheimer’s disease impacts that receptor and weakens synaptic connections between brain cells.

Fear responses can only be erased when people learn something new while retrieving the fear memory. This is the conclusion of a study conducted by scientists from the University of Amsterdam (UvA) and published in the leading journal Science.

Injuries that result in chronic pain, such as limb injuries, and those unrelated to the brain are associated with epigenetic changes in the brain which persist months after the injury, according to researchers at McGill University.

Montreal researchers find that music lessons before age seven create stronger connections in the brain.

A team of political scientists and neuroscientists has shown that liberals and conservatives use different parts of the brain when they make risky decisions, and these regions can be used to predict which political party a person prefers.


Why breaking New Year’s resolutions is all in the mind

resolutionsHappy New Year! So have you made any new year’s resolutions this year? Despite the high failure rate of these resolutions – research by British psychologist Richard Wiseman in 2007  has shown that 88% of all resolutions end in failure – many continue to make the same resolutions year in and year out. But just why are our old habits  so hard to break?

The science of willpower

The brain area largely responsible for willpower is the prefrontal cortex ( located just behind the forehead). This area of the brain is also in charge of keeping us focused, handling short-term memory and solving abstract problems.

Author Johan Lehrer writing in the Wall Street Journal proposed that adding new year’s resolutions to an overloaded prefrontal cortex is a sure-fire recipe for failure.

He refered to an experiment led by Baba Shiv at Stanford University, where several dozen undergraduates were divided into two groups. One group was given a two-digit number to remember, while the second group was given a seven-digit number. Then they were told to walk down the hall, where they were presented with two different snack options: a slice of chocolate cake or a bowl of fruit salad.

What do you think happened?

The students with seven digits to remember were nearly twice as likely to choose the cake as students given two digits. The reason, according to Prof. Shiv, is that those extra numbers took up valuable space in the brain—they were a “cognitive load”—making it that much harder to resist a decadent dessert. In other words, willpower is so weak, and the prefrontal cortex is so overtaxed, that all it takes is five extra bits of information before the brain starts to give in to temptation. “A tired brain, preoccupied with its problems, is going to struggle to resist what it wants, even when what it wants isn’t what we need.” writes Lehrer.

So instead of blaming our own lack of discipline in not keeping to our resolutions, perhaps this research shows that  the power of will is not enough due to the very nature of the brain.

So now we know what doesn’t work when it comes to keeping those resolutions, let’s take a look at what might help.

How to keep New Year’s resolutions

Lehrer suggests we think of willpower as a muscle that needs to be strengthened. Prof Roy Baumeister, a psychologist at Florida State University who has pioneered the muscle metaphor, suggests that it might be possible to strengthen willpower by exercising it.

He asked a group of students to improve their posture for two weeks, thereby practicing mental discipline in one area. The students showed a marked improvement on subsequent measures of self-control, at least when compared to a group that didn’t work on posture control.

If this sounds like too much hard work, you could always try the tried and tested goal setting approach to making positive change stick.

Goal Setting

Think about some small changes you could make in your lifestyle that would help to bring about your ultimate goal.  The cumulative impact of a modest change to your daily routine will restore in you the feeling that you are in control.

Above all, don’t  use your resolutions as a stick to beat yourself with. Ditch the negative connotations and instead focus on what those small changes will bring to your life in a positive way in the coming year.

Finally, here’s an interesting video from Dr Mike Evans on New Year’s Resolutions.


Sorry I’m late, it’s all down to my chronobiology

Photograph: Getty Images

Individuals differ in terms of their chronotype – that is to say whether you are morning oriented or evening oriented, or somewhere in the middle.

We are well into party season as the holidays approach, with dinners, drinks with friends and similar festive cheer. But in the midst of all the fun there is also an annoyance: the latecomer.

Everyone knows someone who is always late. Maybe you’re one of those people yourself. Theories on why some individuals are late on a regular basis come from a variety of perspectives – anthropological, cultural, neurological and psychological. But are there scientific explanations for chronic lateness?

We are all governed by our circadian clocks. The study of this internal clock comes under the heading of chronobiology. “Circadian rhythms are internal 24-hour rhythms created by the Earth spinning on its axis within a 24-hour period,” says Dr Andrew Coogan, a chronobiologist at NUI Maynooth.

“Life has evolved to take advantage of that. Through evolution we have adapted a time-keeping mechanism. Animals and organisms can anticipate changes in their environment and then react appropriately. It’s important particularly for preyed-upon animals, who know to get home before it’s dark.”

The existence of circadian rhythms was first demonstrated in the 1960s when human subjects were placed into a timeless environment – a concealed former second World War bunker to be exact – with no time-reference points, clocks, natural light and so on.

It was found that the volunteers still expressed 24-hour rhythms through their internal clock. They had energy at appropriate times, slept at night time and were awake during the day.

But circadian rhythms affect individuals differently and can lead to inclinations towards “morningness” or “eveningness” and, in turn, “lateness”.

“Individuals differ in terms of their chronotype – that is to say whether you are morning oriented or evening oriented, or somewhere in the middle,” says Coogan.

“This is both an individual characteristic but also changes across the lifespan so small children generally are morning oriented, teenagers tend towards eveningness, then back towards the morning in adulthood.

“This affects the time of day we are most alert and our cognitive prowess is best set up for. Such individual differences seem to be down in part to genetics, but may also be driven by environmental factors – TVs, computers in bedrooms and street lighting at night might all make for a tendency toward ‘eveningness’.

“It might also explain in part lateness. If you are trying to get out of bed and get to school early yet your body clock is not attuned to that rhythm you may struggle and end up being late. So some of us may be predisposed to be late at different times of the day – probably most pertinent to the morning.”

The inclination towards morningness and eveningness also relates to personality. Eveningness tends to be associated with creativity and impulsiveness.

“Plus if you’re a strongly creative person you lose a sense of time when you’re in the middle of something you find very interesting – otherwise known as the absent-minded professor effect,” says Billy O’Connor, professor of physiology in the Graduate Entry Medical School in the University of Limerick.

“People get so engrossed in what they’re doing, they lose any sense of time. It’s actually a sign of good mental health. But it can be very frustrating for other people.”

Morning people, on the other hand, tend more towards conscientiousness and better organisational skills.

“Some people are future oriented so time is very important to them,” says Coogan. “Those who live in the present are not so bothered with being late.”

Being late for a flight or an important meeting is stressful and some people get addicted to that feeling. “Creating a stressful environment can be used by people to up their game,” says O’Connor. “It helps some people focus but you can become addicted to stress, more specifically the hormone cortisol. Its release gets you whizzing along when you need it most.

“Chronic stress ages the body and the brain. So this kind of behaviour works in the short term and does help some people get more done in their lives. But the brain performs optimally when it is calm and focused.”

There is, of course, one other reason why 3pm means 3.30pm to some people. “It can be a power thing,” says O’Connor. “In a business meeting setting, for example, which is a complex social gathering with multiple agendas and strict rules of engagement. They are not casual affairs so being constantly late for a meeting without a valid reason may be regarded as discourteous in a group.

“It may also be regarded as attention seeking, selfish behaviour and signs of a disorganised mind, and will more than likely result in social exclusion,” he says.

JOHN HOLDEN

This article appeared in the Irish Times 19-12-12

Image Credit: Getty Images


Weekly Neuroscience Update

medium_6835040374Two recent pieces of work raise the prospect of being able to predict and even regulate a person’s risk-taking behavior, by first observing activity of the anterior cingulate cortex and then dialing it up or down.

A new study shows that for millions of individuals around the world who suffer from Generalized Anxiety Disorder (GAD), anger is more than an emotion; it’s an agent that exacerbates their illness.

Brain changes persist for months in children who have sustained a mild traumatic brain injury, or concussion, U.S. researchers say.

Chinese researchers have devised a new technique for reprogramming cells from human urine into immature brain cells that can form multiple types of functioning neurons and glial cells. The technique, published in the journal Nature Methods, could prove useful for studying the cellular mechanisms of neurodegenerative conditions such as Alzheimer’s and Parkinson’s and for testing the effects of new drugs that are being developed to treat them.

Researchers have discovered how the brain assesses confidence in its decisions. The findings explain why some people have better insight into their choices than others.

Scientists have combined and translated two kinds of brain wave recordings into music, transforming one recording (EEG) to create the pitch and duration of a note, and the other (fMRI) to control the intensity of the music.

A compassion-based meditation program can significantly improve a person’s ability to read the facial expressions of others, finds a study published by Social Cognitive and Affective Neuroscience. This boost in empathic accuracy was detected through both behavioral testing of the study participants and through functional magnetic resonance imaging (fMRI) scans of their brain activity.

Your brain has at least four different senses of location — and perhaps as many as 10. And each is different, according to new research from the Kavli Institute for Systems Neuroscience, at the Norwegian University of Science and Technology.

photo credit: Amanda Nicole Betley via photopin cc


How alcohol affects your brain

Find out how alcohol molecules alter your brain.


Which sound does our brain most hate to hear?

Picture: shelbyasteward, flickr.com

Scientists from Newcastle University have drawn up a league table of the least pleasant sounds we may encounter as part of everyday life – albeit a slightly old-fashioned life as the top five include the rasp of chalk on a blackboard.

Working with 13 volunteers, they tested reactions to 74 different noises both in outward response and more closely via small changes in the brain.

The results are published in the latest issue of the Journal of Neuroscience and show, among other things, that acoustically anything in the frequency range of around 2,000 to 5,000 Hz was found to be unpleasant.

Continue reading….


What stress does to your brain

A brain drawing with the prefrontal cortex highlighted.

By watching individual neurons at work, a group of psychologists at the University of Wisconsin-Madison has revealed just how stress can addle the mind, as well as how neurons in the brain’s prefrontal cortex help “remember” information in the first place.

Read this story in full here


Weekly Neuroscience Update

New research from Weizmann Institute, published in Nature Neuroscience has discovered that people can actually learn during sleep, which can unconsciously modify their behavior while awake.

Studies have shown that listening to music can soothe hospital patients, improve stroke outcomes and promote the releaseof the neurotransmitter dopamine in the brain sending pleasure signals throughout the body. Now findings recently presented at the Association for the Scientific Study of Consciousness suggest that playing familiar music could enhance cognitive response among patients with brain damage.

In a major development  Bionic Vision Australia researchers have successfully performed the first implantation of an early prototype bionic eye with 24 electrodes.

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

In a study published in the Journal of Neurology, researchers claim that because Attention Deficit Hyperactivity Disorder (ADHD), Fetal Alcohol Spectrum Disorder (FASD) and Parkinson’s Disease (PD) each involve ocular control and attention dysfunctions, they can be easily identified through an evaluation of how patients move their eyes while they watch television.

A new study by researchers at NYU School of Medicine reveals for the first time that metabolic syndrome (MetS) is associated with cognitive and brain impairments in adolescents and calls for pediatricians to take this into account when considering the early treatment of childhood obesity.

People whose blood sugar is on the high end of the normal range may be at greater risk of brain shrinkage that occurs with aging and diseases such as dementia, according to new research published in the September 4, 2012, print issue of Neurology®, the medical journal of the American Academy of Neurology.


Weekly Neuroscience Update

Researchers have found that neurons in a specific region of the frontal cortex, called the anterior cingulate cortex, become active during decisions involving competitive effort.

In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.

Researchers have shown that activity in a certain region of the brain changes as children learn to reason about what other people might be thinking.

The human brain contains billions of neurons that are arranged in complex circuits, which enable people to function with regard to controlling movements, perceiving the world and making decisions. In order to understand how the brain works and what malfunctions occur in neurological disorders it is crucial to decipher these brain circuits. A new study, which is featured in the August 9 edition of Nature reveals that MIT neuroscientists have now come closer towards this goal, by discovering that two major classes of brain cells repress neural activity in specific mathematical ways by which one type subtracting from overall activation, whilst the other type divides it.

That fact that heavy drinking impacts the brain of developing youths is a well-known fact. However, now researchers from the University of California, San Diego School of Medicine and VA San Diego Healthcare System have discovered that certain patterns of brain activity could also help to predict which youths are at risk of becoming problem drinkers. The study is featured online in the August edition of the Journal of Studies on Alcohol and Drugs. The study involved functional magnetic resonance imaging (fMRI) of 12 to 16 year old teenagers’ brains before they started drinking and who had an fMRI three years later. About half of the teenagers started drinking heavily over the 3-year period but the researchers noted that the fMRI scans taken before these group of teenagers started drinking, they already showed less fMRI response in areas of the brain that were associated earlier with heavy drinking.

Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

Neuroscientists from The Scripps Institute have identified a specialized population of stem cells that have an impressive vocational calling: higher brain functioning. It’s an important finding that holds promise for the treatments of serious cognitive disorders — including those that impact on conscious function. And it also reveals how humans and other mammals are able to have such big brains.

Neuroscientists have discovered that the universal saying of “living in the moment” may be impossible. A study published in the journal Neuron reveals that neuroscientists have identified an area in the brain, which is responsible for using past decisions and outcomes to guide future behavior. The study is the first of its kind to analyze signals linked to metacognition, known as a person’s ability to monitor and control cognition, which researchers describe as “thinking about thinking.”


Weekly Neuroscience Update

Research from the University of Southampton, which examines how dolphins might process their sonar signals, could provide a new system for man-made sonar to detect targets, such as sea mines, in bubbly water.

Evidence is mounting that exercise provides some protection from memory loss and Alzheimer’s disease, with three new studies showing that a variety of physical activities are associated with healthier brains in older adults.

Researchers  have discovered an important clue to how the human brain —important clue to how the human brain — which is constantly bombarded with millions of pieces of visual information, can filter out what’s unimportant and focus on what’s most useful.

Scientists at the California Institute of Technology (Caltech) pioneered the study of the link between irregularities in the immune system and neurodevelopmental disorders such as autism a decade ago. Since then, studies of postmortem brains and of individuals with autism, as well as epidemiological studies, have supported the correlation between alterations in the immune system and autism spectrum disorder.

Researchers at Aalto University in Finland have developed the world’s first device designed for mapping the human brain that combines whole-head magnetoencephalography (MEG) and magnetic resonance imaging (MRI) technology. MEG measures the electrical function and MRI visualizes the structure of the brain. The merging of these two technologies will produce unprecedented accuracy in locating brain electrical activity non-invasively. 

Cognition psychologists have discovered why stressed persons are more likely to lapse back into habits than to behave goal-directed. The researchers have now reported in the Journal of Neuroscience that the interaction of the stress hormones hydrocortisone and noradrenaline shut down the activity of brain regions for goal-directed behaviour. The brain regions responsible for habitual behaviour remained unaffected.

Raising levels of the neurotransmitter dopamine in the frontal cortex of the brain significantly decreased impulsivity in healthy adults, in a study conducted by researchers at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco


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